Maintenance in gastric cancer: New life for an old issue?

Giandomenico Roviello, Maria Grazia Rodriquenz, Giuseppe Aprile, Alberto D'Angelo, Franco Roviello, Stefania Nobili, Enrico Mini, Italo Sarno, Karol Polom

Research output: Contribution to journalReview articlepeer-review

4 Citations (SciVal)
31 Downloads (Pure)


The interest in maintenance therapy for patients with advanced cancers has been rapidly growing. Maintenance therapy is a useful strategy that may strengthen results of induction therapy thus extending survival and preserving the quality of life (QoL) with less toxicity. Maintenance also represents a suitable setting to investigate novel agents. The value of maintenance therapy after first-line chemotherapy has been well established in several solid tumours, such as colorectal, lung, breast, and ovarian cancer in which it is largely adopted. To date, there is no established role for maintenance therapy following first-line chemotherapy for advanced gastric cancer (GC). This review summarizes the current knowledge regarding maintenance strategies in advanced GC exploring cytotoxic agents, biologic agents and immunotherapy. We also critically review new issues to optimize randomized clinical trials for maintenance therapies and suggest clinical consideration to guide a personalized approach in daily clinical practice for this setting.

Original languageEnglish
Article number103307
JournalCritical Reviews in Oncology/Hematology
Early online date19 Mar 2021
Publication statusPublished - 30 Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Copyright 2021 Elsevier B.V., All rights reserved.


  • First-line
  • Gastric cancer
  • Maintenance

ASJC Scopus subject areas

  • Hematology
  • Oncology


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