Abstract
Rare actinomycetes are a source of numerous diverse, biologically active secondary metabolites, including
macrolides, which have been shown to display several antibiotic activities. The bioactivities and representative structures of 26 groups of macrolides from rare actinomycetes are presented in this review.
The most interesting groups, with a wide range of biological activities, are ammocidins, bafilomycins,
neomaclafungins, rosaramicins, spinosyns, and tiacumicins. Most macrolides are from the genus, Micromonospora, with smaller contributions from genera such as Saccharothrix, Amycolatopsis, Nocardiopsis and Catenulispora. These macrolides display unique cytotoxic, antibacterial, antifungal, antimicrobial,
insecticidal, anti-trypanosomal, antimalarial, antiprotozoal, antimycobacterial and anti-herpetic activity.
Considering their bioactivities and diverse structures, macrolides from rare actinomycetes warrant further
investigation for future applications in medicine. This work highlights the bioactivities and structures of
important classes of macrolides from rare actinomycetes that are already marketed or could be used in
medicine in the future.
macrolides, which have been shown to display several antibiotic activities. The bioactivities and representative structures of 26 groups of macrolides from rare actinomycetes are presented in this review.
The most interesting groups, with a wide range of biological activities, are ammocidins, bafilomycins,
neomaclafungins, rosaramicins, spinosyns, and tiacumicins. Most macrolides are from the genus, Micromonospora, with smaller contributions from genera such as Saccharothrix, Amycolatopsis, Nocardiopsis and Catenulispora. These macrolides display unique cytotoxic, antibacterial, antifungal, antimicrobial,
insecticidal, anti-trypanosomal, antimalarial, antiprotozoal, antimycobacterial and anti-herpetic activity.
Considering their bioactivities and diverse structures, macrolides from rare actinomycetes warrant further
investigation for future applications in medicine. This work highlights the bioactivities and structures of
important classes of macrolides from rare actinomycetes that are already marketed or could be used in
medicine in the future.
| Original language | English |
|---|---|
| Article number | 106523 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 59 |
| Issue number | 2 |
| Early online date | 15 Jan 2022 |
| DOIs | |
| Publication status | Published - 28 Feb 2022 |
Bibliographical note
Funding Information:This project is jointly supported from Aberystwyth University and council for academics at risk (CARA). Funding: None, Competing Interests: All the authors declare that they have no conflict of interest. Ethical Approval: Not applicable
Publisher Copyright:
© 2022 Elsevier Ltd
Keywords
- Antibacterial, Antifungal, Antimicrobial
- Cytotoxic
- Macrolide
- Rare actinomycetes
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)
