Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

Meng Li; Haobo Ge; Vincenzo Mirabello; Rory L. Arrowsmith; Gabriele Kociok-Kohn; Stanley W Botchway; Weihong Zhu; Sofia I. Pascu; Tony D. James

doi:10.1039/C7CC05166B

Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

Meng Li, Haobo Ge, Vincenzo Mirabello, Rory L. Arrowsmith, Gabriele Kociok-Kohn, Stanley W Botchway, Weihong Zhu, Sofia I. Pascu, Tony D. James

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Abstract

A naphthalimide-based chemosensing motif turns ON the fluorescence emission in solution in the presence of aqueous iron(III) chloride, and maintains this property in living cancer cells. The emission response to Fe(III) ions occurs simultaneously with a change in pH. The protonation of methyl piperazine-conjugated naphthalimide promotes its lysosomal localisation as assessed by co-localisation tests and fluorescence lifetime imaging microscopy (FLIM) in vitro.

Original language	English
Pages (from-to)	11161-11164
Journal	Chemical Communications
Volume	53
Issue number	81
Early online date	1 Sept 2017
DOIs	https://doi.org/10.1039/C7CC05166B
Publication status	Published - 18 Oct 2017

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SDG 3 Good Health and Well-being

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Published VersionFinal published version, 2.07 MBLicence: CC BY

Cite this

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title = "Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy",

abstract = "A naphthalimide-based chemosensing motif turns ON the fluorescence emission in solution in the presence of aqueous iron(III) chloride, and maintains this property in living cancer cells. The emission response to Fe(III) ions occurs simultaneously with a change in pH. The protonation of methyl piperazine-conjugated naphthalimide promotes its lysosomal localisation as assessed by co-localisation tests and fluorescence lifetime imaging microscopy (FLIM) in vitro.",

author = "Meng Li and Haobo Ge and Vincenzo Mirabello and Arrowsmith, \{Rory L.\} and Gabriele Kociok-Kohn and Botchway, \{Stanley W\} and Weihong Zhu and Pascu, \{Sofia I.\} and James, \{Tony D.\}",

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doi = "10.1039/C7CC05166B",

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T1 - Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

AU - Li, Meng

AU - Ge, Haobo

AU - Mirabello, Vincenzo

AU - Arrowsmith, Rory L.

AU - Kociok-Kohn, Gabriele

AU - Botchway, Stanley W

AU - Zhu, Weihong

AU - Pascu, Sofia I.

AU - James, Tony D.

PY - 2017/10/18

Y1 - 2017/10/18

N2 - A naphthalimide-based chemosensing motif turns ON the fluorescence emission in solution in the presence of aqueous iron(III) chloride, and maintains this property in living cancer cells. The emission response to Fe(III) ions occurs simultaneously with a change in pH. The protonation of methyl piperazine-conjugated naphthalimide promotes its lysosomal localisation as assessed by co-localisation tests and fluorescence lifetime imaging microscopy (FLIM) in vitro.

AB - A naphthalimide-based chemosensing motif turns ON the fluorescence emission in solution in the presence of aqueous iron(III) chloride, and maintains this property in living cancer cells. The emission response to Fe(III) ions occurs simultaneously with a change in pH. The protonation of methyl piperazine-conjugated naphthalimide promotes its lysosomal localisation as assessed by co-localisation tests and fluorescence lifetime imaging microscopy (FLIM) in vitro.

UR - http://dx.doi.org/10.1039/C7CC05166B

UR - https://www.scopus.com/pages/publications/85030989107

U2 - 10.1039/C7CC05166B

DO - 10.1039/C7CC05166B

M3 - Article

SN - 1359-7345

VL - 53

SP - 11161

EP - 11164

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

Lysosomal tracking with a cationic naphthalimide using multiphoton fluorescence lifetime imaging microscopy

Abstract

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