Low-Cost Optical Assays for Point-of-Care Diagnosis in Resource-Limited Settings

Nan Jiang; Natha Dean Tansukawat; Laura Gonzalez-Macia; H. Ceren Ates; Can Dincer; Firat Güder; Savas Tasoglu; Ali K. Yetisen

doi:10.1021/acssensors.1c00669

Low-Cost Optical Assays for Point-of-Care Diagnosis in Resource-Limited Settings

Nan Jiang, Natha Dean Tansukawat, Laura Gonzalez-Macia, H. Ceren Ates, Can Dincer, Firat Güder, Savas Tasoglu, Ali K. Yetisen

Research output: Contribution to journal › Review article › peer-review

95 Citations (SciVal)

Abstract

Readily deployable, low-cost point-of-care medical devices such as lateral flow assays (LFAs), microfluidic paper-based analytical devices (μPADs), and microfluidic thread-based analytical devices (μTADs) are urgently needed in resource-poor settings. Governed by the ASSURED criteria (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverability) set by the World Health Organization, these reliable platforms can screen a myriad of chemical and biological analytes including viruses, bacteria, proteins, electrolytes, and narcotics. The Ebola epidemic in 2014 and the ongoing pandemic of SARS-CoV-2 have exemplified the ever-increasing importance of timely diagnostics to limit the spread of diseases. This review provides a comprehensive survey of LFAs, μPADs, and μTADs that can be deployed in resource-limited settings. The subsequent commercialization of these technologies will benefit the public health, especially in areas where access to healthcare is limited.

Original language	English
Pages (from-to)	2108-2124
Number of pages	17
Journal	ACS Sensors
Volume	6
Issue number	6
Early online date	2 Jun 2021
DOIs	https://doi.org/10.1021/acssensors.1c00669
Publication status	Published - 25 Jun 2021

Acknowledgements

A.K.Y. thanks the Engineering and Physical Sciences Research Council (EPSRC) for a New Investigator Award (EP/T013567/1). N.J. is supported by “the Fundamental Research Funds for the Central Universities of China (YJ202152)”. S.T. acknowledges Alexander von Humboldt Research Fellowship for Experienced Researchers, Marie Skłodowska-Curie Individual Fellowship (101003361), and Royal Academy Newton Katip Çelebi Transforming Systems Through Partnership award (120N019) for financial support of this research. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the TÜ BITAK. H.C.A. and C.D. would like to thank the Deutsche ̇Forschungsgemeinschaft (DFG, German Research Foundation) for partially funding this work under grant number 404478562.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

lateral flow assays
low-cost
on-site testing
paper-based analytical devices
paper-based sensors
point-of-care medical devices
resource-limited settings
SARS-CoV-2
thread-based sensors

ASJC Scopus subject areas

Bioengineering
Instrumentation
Process Chemistry and Technology
Fluid Flow and Transfer Processes

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10.1021/acssensors.1c00669

Cite this

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abstract = "Readily deployable, low-cost point-of-care medical devices such as lateral flow assays (LFAs), microfluidic paper-based analytical devices (μPADs), and microfluidic thread-based analytical devices (μTADs) are urgently needed in resource-poor settings. Governed by the ASSURED criteria (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverability) set by the World Health Organization, these reliable platforms can screen a myriad of chemical and biological analytes including viruses, bacteria, proteins, electrolytes, and narcotics. The Ebola epidemic in 2014 and the ongoing pandemic of SARS-CoV-2 have exemplified the ever-increasing importance of timely diagnostics to limit the spread of diseases. This review provides a comprehensive survey of LFAs, μPADs, and μTADs that can be deployed in resource-limited settings. The subsequent commercialization of these technologies will benefit the public health, especially in areas where access to healthcare is limited.",

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Low-Cost Optical Assays for Point-of-Care Diagnosis in Resource-Limited Settings

Abstract

Acknowledgements

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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