Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Adam C. Sedgwick; Hai Hao Han; Jordan E. Gardiner; Steven D. Bull; Xiao-Peng He; Tony D. James

doi:10.1039/C7CC07845E

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Adam C. Sedgwick, Hai Hao Han, Jordan E. Gardiner, Steven D. Bull, Xiao-Peng He, Tony D. James

Department of Chemistry

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

117 Citations (SciVal)

Abstract

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

Original language	English
Pages (from-to)	12822-12825
Journal	Chemical Communications
Volume	53
Issue number	95
DOIs	https://doi.org/10.1039/C7CC07845E
Publication status	Published - 11 Dec 2017

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abstract = "Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).",

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AU - Gardiner, Jordan E.

AU - Bull, Steven D.

AU - He, Xiao-Peng

AU - James, Tony D.

PY - 2017/12/11

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N2 - Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

AB - Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

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DO - 10.1039/C7CC07845E

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VL - 53

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Abstract

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