Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Adam C. Sedgwick, Hai Hao Han, Jordan E. Gardiner, Steven D. Bull, Xiao-Peng He, Tony D. James

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).
Original languageEnglish
Pages (from-to)12822-12825
JournalChemical Communications
Volume53
Issue number95
DOIs
Publication statusPublished - 11 Dec 2017

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Mitochondria
Peroxynitrous Acid
Solubility
Imaging techniques
Wavelength
Fluorescent Dyes

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Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite. / Sedgwick, Adam C.; Han, Hai Hao; Gardiner, Jordan E.; Bull, Steven D.; He, Xiao-Peng; James, Tony D.

In: Chemical Communications, Vol. 53, No. 95, 11.12.2017, p. 12822-12825.

Research output: Contribution to journalArticle

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