Long non-coding RNAs in the regulation of the immune response

J.A. Heward, M.A. Lindsay

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It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of lncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These lncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein-protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related lncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and lncRNA biology.
Original languageEnglish
Pages (from-to)408-419
Number of pages12
JournalTrends in Immunology
Issue number9
Early online date8 Aug 2014
Publication statusPublished - Sept 2014


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