Long Non-coding RNAs in Rheumatology

Susanne N. Wijesinghe, Mark A. Lindsay, Simon W. Jones

Research output: Chapter or section in a book/report/conference proceedingChapter or section

Abstract

The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as non-protein encoding RNA transcripts that exceed 200 nucleotides in length. These transcripts have tissue and cell specific patterns of expression and are implicated in a variety of biological processes. Unsurprisingly, numerous lncRNAs are dysregulated in rheumatoid conditions, correlating with disease activity and cited as potential biomarkers and targets for therapeutic intervention. In this chapter, following an introduction into each condition, we discuss the lncRNAs involved in rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus. These inflammatory joint conditions share several inflammatory signalling pathways and therefore not surprisingly many commonly dysregulated lncRNAs are shared across these conditions. In the interest of translational research only those lncRNAs which are strongly conserved have been addressed. The lncRNAs discussed here have diverse roles in regulating inflammation, proliferation, migration, invasion and apoptosis. Understanding the molecular basis of lncRNA function in rheumatology will be crucial in fully determining the inflammatory mechanisms that drive these conditions.

Original languageEnglish
Title of host publicationLong Noncoding RNA
EditorsS. Carpenter
Place of PublicationCham, Switzerland
PublisherSpringer
Pages35-70
Number of pages36
ISBN (Electronic)9783030920340
ISBN (Print)9783030920333
DOIs
Publication statusPublished - 27 Feb 2022

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer New York
Volume1363
ISSN (Print)0065-2598

Keywords

  • Inflammation
  • Long noncoding RNA
  • Osteoarthritis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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