Localised interventions in cellular processes

Nick Peel, Banafshé Larijani, Peter J. Parker

Research output: Contribution to journalReview articlepeer-review

Abstract

The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).

Original languageEnglish
Pages (from-to)1364-1370
Number of pages7
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1834
Issue number7
Early online date30 Jan 2013
DOIs
Publication statusPublished - 1 Jul 2013

Keywords

  • Dimerization
  • Inhibitor
  • Membrane
  • Phospholipid
  • Rapalogue
  • Spatial signaling

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this