Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

Ian S Blagbrough; A J Geall; S A David

doi:10.1016/S0960-894X(00)00380-2

Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

Ian S Blagbrough
, A J Geall
, S A David

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

33 Citations (SciVal)

Abstract

Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.

Original language	English
Pages (from-to)	1959-1962
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	10
Issue number	17
DOIs	https://doi.org/10.1016/S0960-894X(00)00380-2
Publication status	Published - 2000

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title = "Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide",

abstract = "Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.",

author = "Blagbrough, \{Ian S\} and Geall, \{A J\} and David, \{S A\}",

year = "2000",

doi = "10.1016/S0960-894X(00)00380-2",

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journal = "Bioorganic \& Medicinal Chemistry Letters",

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T1 - Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

AU - Blagbrough, Ian S

AU - Geall, A J

AU - David, S A

PY - 2000

Y1 - 2000

N2 - Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.

AB - Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.

U2 - 10.1016/S0960-894X(00)00380-2

DO - 10.1016/S0960-894X(00)00380-2

M3 - Article

SN - 0960-894X

VL - 10

SP - 1959

EP - 1962

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 17

ER -

Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide

Abstract

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