Lipid/Protein Interactions and the Membrane/Water Interfacial Region

Carmen Domene Nunez, Peter J. Bond, Sundeep S Deol, Mark S. P. Sansom

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Despite the importance of lipid/protein interactions in the folding, assembly, stability, and function of membrane proteins, information at an atomic level on how such proteins interact with the lipids that surround them remains sparse. The dynamics and flexible nature of the protein/bilayer interaction make it difficult to study, for example, by crystallographic means. However, based on recent progress in molecular simulations of membranes it is possible to address this problem computationally. This communication reports one of the first attempts to use multiple ns molecular simulations to establish a qualitative picture of the intermolecular interactions between the lipids of a bilayer and two topologically different membrane proteins for which a high resolution (2 Å or better) X-ray structure is available.
Original languageEnglish
Pages (from-to)14966-14967
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number49
DOIs
Publication statusPublished - 1 Dec 2003

Keywords

  • Bacterial Outer Membrane Proteins, Bacterial Proteins, Computer Simulation, Dimyristoylphosphatidylcholine, Lipid Bilayers, Models, Molecular, Phosphatidylcholines, Potassium Channels, Water

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