Limitations in study design hamper interpretation of studies evaluating the prognostic value of nailfold capillaroscopy in systemic sclerosis: a systematic literature review

Dolcie Paxton, John D Pauling

Research output: Contribution to journalMeeting abstract

Abstract

Background: Nailfold capillaroscopy (NC) is a valuable diagnostic tool in systemic sclerosis (SSc). Increasing attention has focused on the prognostic potential of NC in predicting disease outcomes in SSc. Confirmation of the prognostic value of NC could facilitate earlier intervention and improve outcomes in SSc. We report a systematic literature review evaluating the prognostic value of NC in predicting disease outcomes in SSc.Methods: The review was conducted according to PRISMA guidelines (PROSPERO 2017: CRD42017071719). Standardised searches of EMBASE and MEDLINE (through July 2017) were undertaken to identify longitudinal studies examining the prognostic potential of NC in SSc. Non-English, non-original research, animal studies, non-adult studies and non-full length reports were excluded. The QUality In Prognosis Studies (QUIPS) tool was used to evaluate the risk of bias across six domains (Table 1). Study selection, data extraction and risk-of-bias assessment were undertaken independently by two reviewers and consensus reached where necessary.
Original languageEnglish
Article number202
Number of pages1
JournalRheumatology
Volume57
Issue numbersuppl_3
Early online date25 Apr 2018
DOIs
Publication statusPublished - 30 Apr 2018

Cite this

@article{e53dcc268ff64a2aa27d33ada77825ae,
title = "Limitations in study design hamper interpretation of studies evaluating the prognostic value of nailfold capillaroscopy in systemic sclerosis: a systematic literature review",
abstract = "Background: Nailfold capillaroscopy (NC) is a valuable diagnostic tool in systemic sclerosis (SSc). Increasing attention has focused on the prognostic potential of NC in predicting disease outcomes in SSc. Confirmation of the prognostic value of NC could facilitate earlier intervention and improve outcomes in SSc. We report a systematic literature review evaluating the prognostic value of NC in predicting disease outcomes in SSc.Methods: The review was conducted according to PRISMA guidelines (PROSPERO 2017: CRD42017071719). Standardised searches of EMBASE and MEDLINE (through July 2017) were undertaken to identify longitudinal studies examining the prognostic potential of NC in SSc. Non-English, non-original research, animal studies, non-adult studies and non-full length reports were excluded. The QUality In Prognosis Studies (QUIPS) tool was used to evaluate the risk of bias across six domains (Table 1). Study selection, data extraction and risk-of-bias assessment were undertaken independently by two reviewers and consensus reached where necessary.",
author = "Dolcie Paxton and Pauling, {John D}",
year = "2018",
month = "4",
day = "30",
doi = "10.1093/rheumatology/key075.426",
language = "English",
volume = "57",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "suppl_3",

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TY - JOUR

T1 - Limitations in study design hamper interpretation of studies evaluating the prognostic value of nailfold capillaroscopy in systemic sclerosis: a systematic literature review

AU - Paxton, Dolcie

AU - Pauling, John D

PY - 2018/4/30

Y1 - 2018/4/30

N2 - Background: Nailfold capillaroscopy (NC) is a valuable diagnostic tool in systemic sclerosis (SSc). Increasing attention has focused on the prognostic potential of NC in predicting disease outcomes in SSc. Confirmation of the prognostic value of NC could facilitate earlier intervention and improve outcomes in SSc. We report a systematic literature review evaluating the prognostic value of NC in predicting disease outcomes in SSc.Methods: The review was conducted according to PRISMA guidelines (PROSPERO 2017: CRD42017071719). Standardised searches of EMBASE and MEDLINE (through July 2017) were undertaken to identify longitudinal studies examining the prognostic potential of NC in SSc. Non-English, non-original research, animal studies, non-adult studies and non-full length reports were excluded. The QUality In Prognosis Studies (QUIPS) tool was used to evaluate the risk of bias across six domains (Table 1). Study selection, data extraction and risk-of-bias assessment were undertaken independently by two reviewers and consensus reached where necessary.

AB - Background: Nailfold capillaroscopy (NC) is a valuable diagnostic tool in systemic sclerosis (SSc). Increasing attention has focused on the prognostic potential of NC in predicting disease outcomes in SSc. Confirmation of the prognostic value of NC could facilitate earlier intervention and improve outcomes in SSc. We report a systematic literature review evaluating the prognostic value of NC in predicting disease outcomes in SSc.Methods: The review was conducted according to PRISMA guidelines (PROSPERO 2017: CRD42017071719). Standardised searches of EMBASE and MEDLINE (through July 2017) were undertaken to identify longitudinal studies examining the prognostic potential of NC in SSc. Non-English, non-original research, animal studies, non-adult studies and non-full length reports were excluded. The QUality In Prognosis Studies (QUIPS) tool was used to evaluate the risk of bias across six domains (Table 1). Study selection, data extraction and risk-of-bias assessment were undertaken independently by two reviewers and consensus reached where necessary.

U2 - 10.1093/rheumatology/key075.426

DO - 10.1093/rheumatology/key075.426

M3 - Meeting abstract

VL - 57

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - suppl_3

M1 - 202

ER -