Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions

Daniel Baxter, Chris Ullman, Jody Mason

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

In the modern age of proteomics, vast numbers of protein–protein interactions (PPIs) are being identified as causative agents in pathogenesis, and are thus attractive therapeutic targets for intervention. Although traditionally regarded unfavorably as druggable agents relative to small molecules, peptides in recent years have gained considerable attention. Their previous dismissal had been largely due to the susceptibility of unmodified peptides to the barriers and pressures exerted by the circulation, immune system, proteases, membranes and other stresses. However, recent advances in high-throughput peptide isolation techniques, as well as a huge variety of direct modification options and approaches to allow targeted delivery, mean that peptides and their mimetics can now be designed to circumvent many of these traditional barriers. As a result, an increasing number of peptide-based drugs are reaching clinical trials and patients beyond.
Original languageEnglish
Pages (from-to)2073
Number of pages2092
JournalFuture Medicinal Chemistry
Volume6
Issue number18
DOIs
Publication statusPublished - 6 Dec 2014

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