Leukocyte deformation in cardiac assist devices

Katharine Fraser; Ina Laura Pieper

Leukocyte deformation in cardiac assist devices

Katharine Fraser, Ina Laura Pieper

Department of Mechanical Engineering

Swansea University

Research output: Contribution to conference › Paper › peer-review

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Abstract

Ventricular Assist Devices (VADs) are pumps which support failing hearts. While considered by some surgeons as gold standard treatment, current VADs have many complications related to the imposed stress on the blood. In particular, damage to the leukocytes may contribute to infections, currently the biggest post-surgical problem. Our aim was to create a numerical model of a leukocyte
which can be used to investigate leukocyte deformation in VADs. The leukocyte was modelled as a compound liquid droplet and solved in OpenFOAM using the multiphaseInterfoam solver. Initial results are presented for different shear rates, extensional versus planar shear, and for different nucleus sizes.

Original language	English
Pages	442
Number of pages	445
Publication status	Published - 10 Apr 2017
Event	Computational and Mathematical Biomedical Engineering - University of Pittsburgh, Pittsburgh, USA United States Duration: 10 Apr 2017 → 12 Apr 2017 Conference number: 5 http://www.compbiomed.net/2017/cmbe-proceedings.htm

Conference

Conference	Computational and Mathematical Biomedical Engineering
Abbreviated title	CMBE 2017
Country/Territory	USA United States
City	Pittsburgh
Period	10/04/17 → 12/04/17
Internet address	http://www.compbiomed.net/2017/cmbe-proceedings.htm

Access to Document

KHF_CMBE17
CMBE publishes its proceedings in print (ISSN 2227-3085) and in online (ISSN 2227-9385) format. The complete CMBE online proceedings series is available to download. http://www.compbiomed.net/2017/cmbe-proceedings.htm

Calculating the Fate of Leukocytes in Ventricular Assist Devices
Fraser, K. (PI)
The Royal Society
31/03/15 → 30/09/16
Project: Research council

Cite this

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title = "Leukocyte deformation in cardiac assist devices",

abstract = "Ventricular Assist Devices (VADs) are pumps which support failing hearts. While considered by some surgeons as gold standard treatment, current VADs have many complications related to the imposed stress on the blood. In particular, damage to the leukocytes may contribute to infections, currently the biggest post-surgical problem. Our aim was to create a numerical model of a leukocytewhich can be used to investigate leukocyte deformation in VADs. The leukocyte was modelled as a compound liquid droplet and solved in OpenFOAM using the multiphaseInterfoam solver. Initial results are presented for different shear rates, extensional versus planar shear, and for different nucleus sizes.",

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T1 - Leukocyte deformation in cardiac assist devices

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AU - Pieper, Ina Laura

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N2 - Ventricular Assist Devices (VADs) are pumps which support failing hearts. While considered by some surgeons as gold standard treatment, current VADs have many complications related to the imposed stress on the blood. In particular, damage to the leukocytes may contribute to infections, currently the biggest post-surgical problem. Our aim was to create a numerical model of a leukocytewhich can be used to investigate leukocyte deformation in VADs. The leukocyte was modelled as a compound liquid droplet and solved in OpenFOAM using the multiphaseInterfoam solver. Initial results are presented for different shear rates, extensional versus planar shear, and for different nucleus sizes.

AB - Ventricular Assist Devices (VADs) are pumps which support failing hearts. While considered by some surgeons as gold standard treatment, current VADs have many complications related to the imposed stress on the blood. In particular, damage to the leukocytes may contribute to infections, currently the biggest post-surgical problem. Our aim was to create a numerical model of a leukocytewhich can be used to investigate leukocyte deformation in VADs. The leukocyte was modelled as a compound liquid droplet and solved in OpenFOAM using the multiphaseInterfoam solver. Initial results are presented for different shear rates, extensional versus planar shear, and for different nucleus sizes.

M3 - Paper

SP - 442

T2 - Computational and Mathematical Biomedical Engineering

Y2 - 10 April 2017 through 12 April 2017

ER -

Leukocyte deformation in cardiac assist devices

Abstract

Conference

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Projects

Calculating the Fate of Leukocytes in Ventricular Assist Devices

Cite this