TY - JOUR
T1 - Lessons about adolescent unipolar depression from the Improving Mood with Psychoanalytic and Cognitive Therapies Trial
AU - Loades, Maria
AU - Midgley, Nick
AU - Herring, Georgia
AU - O'Keeffe, Sally
AU - Consortium, IMPACT
AU - Reynolds, Shirley
AU - Goodyer, Ian
N1 - Funding for work on this manuscript:
Dr Maria Loades (Development and Skills Enhancement Award, 302367) is funded by the National Institute for Health Research (NIHR) for this research project. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR, NHS or the UK Department of Health and Social Care. None of the other authors received any funding for work on this manuscript.
Funding for the original study:
The IMPACT study was funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project number 06/05/01). The IMPACT-ME study was funded by the Monument Trust. The IMPACT-MR study was funded by a Medical Research Council award (grant no: G0802226). This report is independent research.
PY - 2023/4/22
Y1 - 2023/4/22
N2 - This review paper summarises the results of the IMPACT study and their implications for psychological treatment of adolescents with moderate to severe unipolar major depression. IMPACT (Improving Mood with Psychoanalytic and Cognitive Therapies) was a pragmatic, superiority randomized controlled trial, conducted in the UK, which compared the clinical and cost effectiveness of short-term psychoanalytic therapy (STPP), cognitive behavior therapy (CBT) and a brief psychosocial intervention (BPI) in reducing depression symptoms in 465 adolescents with unipolar major depression, aged 11 to 17 years. Although a clinically heterogeneous group of adolescents, some symptoms (e.g., sleep and concentration difficulties, irritability/anger) were common and disabling. The trial reported no significant difference between the three treatments in reducing depression symptoms. One-year after treatment, 84% of participants showed improvement in depressive symptoms (
AB - This review paper summarises the results of the IMPACT study and their implications for psychological treatment of adolescents with moderate to severe unipolar major depression. IMPACT (Improving Mood with Psychoanalytic and Cognitive Therapies) was a pragmatic, superiority randomized controlled trial, conducted in the UK, which compared the clinical and cost effectiveness of short-term psychoanalytic therapy (STPP), cognitive behavior therapy (CBT) and a brief psychosocial intervention (BPI) in reducing depression symptoms in 465 adolescents with unipolar major depression, aged 11 to 17 years. Although a clinically heterogeneous group of adolescents, some symptoms (e.g., sleep and concentration difficulties, irritability/anger) were common and disabling. The trial reported no significant difference between the three treatments in reducing depression symptoms. One-year after treatment, 84% of participants showed improvement in depressive symptoms (
M3 - Review article
SN - 0890-8567
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
ER -