Large-scale recent expansion of European patrilineages shown by population resequencing

Chiara Batini; Pille Hallast; Daniel Zadik; Pierpaolo Maisano Delser; Andrea Benazzo; Silvia Ghirotto; Eduardo Arroyo-Pardo; Gianpiero L Cavalleri; Peter de Knijff; Berit Myhre Dupuy; Heidi A Eriksen; Turi E King; Adolfo López de Munain; Ana M López-Parra; Aphrodite Loutradis; Jelena Milasin; Andrea Novelletto; Horolma Pamjav; Antti Sajantila; Aslıhan Tolun; Bruce Winney; Mark A Jobling

doi:10.1038/ncomms8152

Large-scale recent expansion of European patrilineages shown by population resequencing

Chiara Batini, Pille Hallast, Daniel Zadik, Pierpaolo Maisano Delser, Andrea Benazzo, Silvia Ghirotto, Eduardo Arroyo-Pardo, Gianpiero L Cavalleri, Peter de Knijff, Berit Myhre Dupuy, Heidi A Eriksen, Turi E King, Adolfo López de Munain, Ana M López-Parra, Aphrodite Loutradis, Jelena Milasin, Andrea Novelletto, Horolma Pamjav, Antti Sajantila, Aslıhan TolunBruce Winney, Mark A Jobling

Research output: Contribution to journal › Article › peer-review

68 Citations (SciVal)

Abstract

The proportion of Europeans descending from Neolithic farmers ∼ 10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have been lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and Middle Eastern populations, defines a phylogeny containing 5,996 single-nucleotide polymorphisms. Dating indicates that three major lineages (I1, R1a and R1b), accounting for 64% of our sample, have very recent coalescent times, ranging between 3.5 and 7.3 KYA. A continuous swathe of 13/17 populations share similar histories featuring a demographic expansion starting ∼ 2.1-4.2 KYA. Our results are compatible with ancient MSY DNA data, and contrast with data on mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the social structure of Bronze Age Europe.

Original language	English
Pages (from-to)	7152
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms8152
Publication status	Published - 19 May 2015

Keywords

Bayes Theorem
Biological Evolution
Computer Simulation
DNA, Mitochondrial/genetics
Demography
Emigration and Immigration
Ethnicity/genetics
Europe
Genetic Variation
Genetics, Population
Genomics
Geography
Haplotypes
History, Ancient
Humans
Male
Middle East
Mutation
Phylogeny
Population Dynamics
Sequence Analysis, DNA
White People/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncomms8152

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Batini, C., Hallast, P., Zadik, D., Delser, P. M., Benazzo, A., Ghirotto, S., Arroyo-Pardo, E., Cavalleri, G. L., de Knijff, P., Dupuy, B. M., Eriksen, H. A., King, T. E., de Munain, A. L., López-Parra, A. M., Loutradis, A., Milasin, J., Novelletto, A., Pamjav, H., Sajantila, A., ... Jobling, M. A. (2015). Large-scale recent expansion of European patrilineages shown by population resequencing. Nature Communications, 6, 7152. https://doi.org/10.1038/ncomms8152

Batini, C, Hallast, P, Zadik, D, Delser, PM, Benazzo, A, Ghirotto, S, Arroyo-Pardo, E, Cavalleri, GL, de Knijff, P, Dupuy, BM, Eriksen, HA, King, TE, de Munain, AL, López-Parra, AM, Loutradis, A, Milasin, J, Novelletto, A, Pamjav, H, Sajantila, A, Tolun, A, Winney, B & Jobling, MA 2015, 'Large-scale recent expansion of European patrilineages shown by population resequencing', Nature Communications, vol. 6, pp. 7152. https://doi.org/10.1038/ncomms8152

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title = "Large-scale recent expansion of European patrilineages shown by population resequencing",

abstract = "The proportion of Europeans descending from Neolithic farmers ∼ 10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have been lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and Middle Eastern populations, defines a phylogeny containing 5,996 single-nucleotide polymorphisms. Dating indicates that three major lineages (I1, R1a and R1b), accounting for 64\% of our sample, have very recent coalescent times, ranging between 3.5 and 7.3 KYA. A continuous swathe of 13/17 populations share similar histories featuring a demographic expansion starting ∼ 2.1-4.2 KYA. Our results are compatible with ancient MSY DNA data, and contrast with data on mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the social structure of Bronze Age Europe.",

keywords = "Bayes Theorem, Biological Evolution, Computer Simulation, DNA, Mitochondrial/genetics, Demography, Emigration and Immigration, Ethnicity/genetics, Europe, Genetic Variation, Genetics, Population, Genomics, Geography, Haplotypes, History, Ancient, Humans, Male, Middle East, Mutation, Phylogeny, Population Dynamics, Sequence Analysis, DNA, White People/genetics",

author = "Chiara Batini and Pille Hallast and Daniel Zadik and Delser, \{Pierpaolo Maisano\} and Andrea Benazzo and Silvia Ghirotto and Eduardo Arroyo-Pardo and Cavalleri, \{Gianpiero L\} and \{de Knijff\}, Peter and Dupuy, \{Berit Myhre\} and Eriksen, \{Heidi A\} and King, \{Turi E\} and \{de Munain\}, \{Adolfo L{\'o}pez\} and L{\'o}pez-Parra, \{Ana M\} and Aphrodite Loutradis and Jelena Milasin and Andrea Novelletto and Horolma Pamjav and Antti Sajantila and Aslıhan Tolun and Bruce Winney and Jobling, \{Mark A\}",

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journal = "Nature Communications",

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AU - Batini, Chiara

AU - Hallast, Pille

AU - Zadik, Daniel

AU - Delser, Pierpaolo Maisano

AU - Benazzo, Andrea

AU - Ghirotto, Silvia

AU - Arroyo-Pardo, Eduardo

AU - Cavalleri, Gianpiero L

AU - de Knijff, Peter

AU - Dupuy, Berit Myhre

AU - Eriksen, Heidi A

AU - King, Turi E

AU - de Munain, Adolfo López

AU - López-Parra, Ana M

AU - Loutradis, Aphrodite

AU - Milasin, Jelena

AU - Novelletto, Andrea

AU - Pamjav, Horolma

AU - Sajantila, Antti

AU - Tolun, Aslıhan

AU - Winney, Bruce

AU - Jobling, Mark A

PY - 2015/5/19

Y1 - 2015/5/19

N2 - The proportion of Europeans descending from Neolithic farmers ∼ 10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have been lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and Middle Eastern populations, defines a phylogeny containing 5,996 single-nucleotide polymorphisms. Dating indicates that three major lineages (I1, R1a and R1b), accounting for 64% of our sample, have very recent coalescent times, ranging between 3.5 and 7.3 KYA. A continuous swathe of 13/17 populations share similar histories featuring a demographic expansion starting ∼ 2.1-4.2 KYA. Our results are compatible with ancient MSY DNA data, and contrast with data on mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the social structure of Bronze Age Europe.

AB - The proportion of Europeans descending from Neolithic farmers ∼ 10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have been lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and Middle Eastern populations, defines a phylogeny containing 5,996 single-nucleotide polymorphisms. Dating indicates that three major lineages (I1, R1a and R1b), accounting for 64% of our sample, have very recent coalescent times, ranging between 3.5 and 7.3 KYA. A continuous swathe of 13/17 populations share similar histories featuring a demographic expansion starting ∼ 2.1-4.2 KYA. Our results are compatible with ancient MSY DNA data, and contrast with data on mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the social structure of Bronze Age Europe.

KW - Bayes Theorem

KW - Biological Evolution

KW - Computer Simulation

KW - DNA, Mitochondrial/genetics

KW - Demography

KW - Emigration and Immigration

KW - Ethnicity/genetics

KW - Europe

KW - Genetic Variation

KW - Genetics, Population

KW - Genomics

KW - Geography

KW - Haplotypes

KW - History, Ancient

KW - Humans

KW - Male

KW - Middle East

KW - Mutation

KW - Phylogeny

KW - Population Dynamics

KW - Sequence Analysis, DNA

KW - White People/genetics

U2 - 10.1038/ncomms8152

DO - 10.1038/ncomms8152

M3 - Article

C2 - 25988751

SN - 2041-1723

VL - 6

SP - 7152

JO - Nature Communications

JF - Nature Communications

ER -

Large-scale recent expansion of European patrilineages shown by population resequencing

Abstract

Keywords

UN SDGs

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