Lactose fluidisation properties and their relationship to dry powder inhaler performance

Hanne Kinnunen; Jagdeep Shur; G Hebbink; A S Muresan; Robert Price

doi:10.1111/j.2042-7158.2010.01178.x

Lactose fluidisation properties and their relationship to dry powder inhaler performance

Hanne Kinnunen, Jagdeep Shur, G Hebbink, A S Muresan, Robert Price

Department of Life Sciences

Research output: Contribution to journal › Article

Abstract

Adding lactose fines to a dry powder inhaler (DPI) formulation is hypothesised to increase the tensile strength of the powder thus resulting in higher fluidisation energy and consequentially in improved drug delivery. The aim of the study was to test the hypothesis. The results show that an increase in fluidisation energy corresponds to an improved DPI performance in the case of micronised fines. With milled fines no such clear link between fluidisation energy and DPI performance was seen.

Original language	English
Pages (from-to)	1342-1343
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	62
Issue number	10
DOIs	https://doi.org/10.1111/j.2042-7158.2010.01178.x
Publication status	Published - Oct 2010
Event	UK PharmSci 2010 - The Science of Medicines - , UK United Kingdom Duration: 1 Sept 2010 → 3 Sept 2010

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title = "Lactose fluidisation properties and their relationship to dry powder inhaler performance",

abstract = "Adding lactose fines to a dry powder inhaler (DPI) formulation is hypothesised to increase the tensile strength of the powder thus resulting in higher fluidisation energy and consequentially in improved drug delivery. The aim of the study was to test the hypothesis. The results show that an increase in fluidisation energy corresponds to an improved DPI performance in the case of micronised fines. With milled fines no such clear link between fluidisation energy and DPI performance was seen.",

author = "Hanne Kinnunen and Jagdeep Shur and G Hebbink and Muresan, {A S} and Robert Price",

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AU - Muresan, A S

AU - Price, Robert

PY - 2010/10

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AB - Adding lactose fines to a dry powder inhaler (DPI) formulation is hypothesised to increase the tensile strength of the powder thus resulting in higher fluidisation energy and consequentially in improved drug delivery. The aim of the study was to test the hypothesis. The results show that an increase in fluidisation energy corresponds to an improved DPI performance in the case of micronised fines. With milled fines no such clear link between fluidisation energy and DPI performance was seen.

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T2 - UK PharmSci 2010 - The Science of Medicines

Y2 - 1 September 2010 through 3 September 2010

ER -

Lactose fluidisation properties and their relationship to dry powder inhaler performance

Abstract

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