Lactose fluidisation properties and their relationship to dry powder inhaler performance

Hanne Kinnunen, Jagdeep Shur, G Hebbink, A S Muresan, Robert Price

Research output: Contribution to journalArticle

Abstract

Adding lactose fines to a dry powder inhaler (DPI) formulation is hypothesised to increase the tensile strength of the powder thus resulting in higher fluidisation energy and consequentially in improved drug delivery. The aim of the study was to test the hypothesis. The results show that an increase in fluidisation energy corresponds to an improved DPI performance in the case of micronised fines. With milled fines no such clear link between fluidisation energy and DPI performance was seen.
Original languageEnglish
Pages (from-to)1342-1343
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume62
Issue number10
DOIs
Publication statusPublished - Oct 2010
EventUK PharmSci 2010 - The Science of Medicines - , UK United Kingdom
Duration: 1 Sep 20103 Sep 2010

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