Label-Free Ultrasensitive Memristive Aptasensor

Ioulia Tzouvadaki, Pawan Jolly, Xiaoling Lu, Sven Ingebrandt, Giovanni de Micheli, Pedro Estrela, Sandro Carrara

Research output: Contribution to journalArticle

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Abstract

We present the very first worldwide ever-reported electrochemical biosensor based on a memristive effect and DNA aptamers. This novel device is developed to propose a completely new approach in cancer diagnostics. In this study, an affinity-based technique is presented for the detection of the prostate specific antigen (PSA) using DNA aptamers. The hysteretic properties of memristive silicon nanowires functionalized with these DNA aptamers provide a label-free and ultrasensitive biodetection technique. The ultrasensitive detection is hereby demonstrated for PSA with a limit of detection down to 23 aM, best ever published value for electrochemical biosensors in PSA detection. The effect of polyelectrolytes on our memristive devices is also reported to further show how positive or negative charges affect the memristive hysteresis. With such an approach, combining memristive nanowires and aptamers, memristive aptamer-based biosensors can be proposed to detect a wide range of cancer markers with unprecedent ultrasensitivities to also address the issue of an early detection of cancer.
Original languageEnglish
Pages (from-to)4472-4476
JournalNano Letters
Volume16
Issue number7
Early online date24 Jun 2016
DOIs
Publication statusPublished - 13 Jul 2016

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Nucleotide Aptamers
Prostate-Specific Antigen
Antigens
Biosensors
Labels
DNA
antigens
Nanowires
bioinstrumentation
deoxyribonucleic acid
cancer
Silicon
Polyelectrolytes
nanowires
Hysteresis
markers
affinity
hysteresis
silicon

Cite this

Tzouvadaki, I., Jolly, P., Lu, X., Ingebrandt, S., de Micheli, G., Estrela, P., & Carrara, S. (2016). Label-Free Ultrasensitive Memristive Aptasensor. Nano Letters, 16(7), 4472-4476. https://doi.org/10.1021/acs.nanolett.6b01648

Label-Free Ultrasensitive Memristive Aptasensor. / Tzouvadaki, Ioulia; Jolly, Pawan; Lu, Xiaoling; Ingebrandt, Sven; de Micheli, Giovanni; Estrela, Pedro; Carrara, Sandro.

In: Nano Letters, Vol. 16, No. 7, 13.07.2016, p. 4472-4476.

Research output: Contribution to journalArticle

Tzouvadaki, I, Jolly, P, Lu, X, Ingebrandt, S, de Micheli, G, Estrela, P & Carrara, S 2016, 'Label-Free Ultrasensitive Memristive Aptasensor', Nano Letters, vol. 16, no. 7, pp. 4472-4476. https://doi.org/10.1021/acs.nanolett.6b01648
Tzouvadaki I, Jolly P, Lu X, Ingebrandt S, de Micheli G, Estrela P et al. Label-Free Ultrasensitive Memristive Aptasensor. Nano Letters. 2016 Jul 13;16(7):4472-4476. https://doi.org/10.1021/acs.nanolett.6b01648
Tzouvadaki, Ioulia ; Jolly, Pawan ; Lu, Xiaoling ; Ingebrandt, Sven ; de Micheli, Giovanni ; Estrela, Pedro ; Carrara, Sandro. / Label-Free Ultrasensitive Memristive Aptasensor. In: Nano Letters. 2016 ; Vol. 16, No. 7. pp. 4472-4476.
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