Label-Free Electrical Biosensor Arrays: A New Challenge for TFT Technology

Biotechnology is in great need of low-cost intelligent biochips capable of massive parallel detection to be used in portable instrumentation. One way this may be achieved is to exploit mature semiconductor technologies for the development of biosensor arrays. We review here two highly promising techniques for label-free electrical detection of biomolecular interactions: potentiometric and electrochemical impedance spectroscopy. Thin film transistor technology can play an important role in the development of these techniques in biosensor microarrays.