Research results are presented providing an empirical examination of the impact of knowledge synthesis and innovative logistics processes on operational flexibility. The research is theoretically grounded in the resource-based view of the firm, augmented with the knowledge-based view. Knowledge synthesis and innovative logistics processes are proposed as key resources in the development of an important logistics capability: operational flexibility. A structural model analysis of survey data collected from logistics executives supports the proposed relationships and indicates that innovative logistics processes can lead to greater operational flexibility. Operational flexibility is also shown to lead to higher levels of logistics performance.