Projects per year
Abstract
Background: Knee loading is associated with the severity and progression of knee osteoarthritis, while knee pain contributes to reduced functional ability and quality of life. In this systematic review, we quantified knee loading and knee pain during different daily activities in people with knee osteoarthritis and explored methodological reasons for differences between studies. Methods: PubMed, Web of Science, Scopus, and manual searches were performed up to July 2024, to retrieve studies measuring knee loading and knee pain in walking, sit-to-stand and stair climbing of people with knee osteoarthritis. Descriptive data synthesis and meta-analysis were performed using a mixed-effect model. Findings: 183 studies were included. Walking led to the greatest knee loading, followed by stair climbing and finally sit-to-stand, although only sit-to-stand was significantly lower than the others (p < 0.001). Stair ascent had the greatest knee pain, followed by walking, stair descent and then sit-to-stand. In addition, our results show a strong negative correlation between knee loading and pain during walking (r = −0.507). Interpretation: The trend of knee loading across activities, while non-significant, is consistent with our previous experimental study. The differences compared to other studies are likely be due to the high heterogeneity in the tested population and differences in methodology. Additionally, there were a substantial number of studies only examining a single activity (primarily walking), which could bias the results. Therefore, future studies should detail participant characteristic and experiment design. In addition, inclusion of a control group is recommended to account for knee loading offsets when comparing results across studies.
Original language | English |
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Article number | 106433 |
Journal | Clinical Biomechanics |
Volume | 122 |
Early online date | 11 Jan 2025 |
DOIs | |
Publication status | E-pub ahead of print - 11 Jan 2025 |
Funding
This study was funded by the China Scholarship Council.
Keywords
- Activity knee pain
- KAM
- KOA
- Knee adduction moment
- Systematic review
- meta-analysis
ASJC Scopus subject areas
- Biophysics
- Orthopedics and Sports Medicine
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Centre for the Analysis of Motion, Entertainment Research and Applications (CAMERA) - 2.0
Campbell, N. (PI), Cosker, D. (PI), Bilzon, J. (CoI), Campbell, N. (CoI), Cazzola, D. (CoI), Colyer, S. (CoI), Cosker, D. (CoI), Lutteroth, C. (CoI), McGuigan, P. (CoI), O'Neill, E. (CoI), Petrini, K. (CoI), Proulx, M. (CoI) & Yang, Y. (CoI)
Engineering and Physical Sciences Research Council
1/11/20 → 31/10/25
Project: Research council
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Centre for the Analysis of Motion, Entertainment Research and Applications (CAMERA)
Cosker, D. (PI), Bilzon, J. (CoI), Campbell, N. (CoI), Cazzola, D. (CoI), Colyer, S. (CoI), Fincham Haines, T. (CoI), Hall, P. (CoI), Kim, K. I. (CoI), Lutteroth, C. (CoI), McGuigan, P. (CoI), O'Neill, E. (CoI), Richardt, C. (CoI), Salo, A. (CoI), Seminati, E. (CoI), Tabor, A. (CoI) & Yang, Y. (CoI)
Engineering and Physical Sciences Research Council
1/09/15 → 28/02/21
Project: Research council