Keep off the grass? Cannabis, cognition and addiction

H Valerie Curran, Tom P Freeman, Claire Mokrysz, David A Lewis, Celia J A Morgan, Loren H Parsons

Research output: Contribution to journalReview articlepeer-review

258 Citations (SciVal)
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In an increasing number of states and countries, cannabis now stands poised to join alcohol and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of cannabis and its constituent cannabinoids should therefore be prioritized. Whereas newspaper headlines have focused on links between cannabis and psychosis, less attention has been paid to the much more common problem of cannabis addiction. Certain cognitive changes have also been attributed to cannabis use, although their causality and longevity are fiercely debated. Identifying why some individuals are more vulnerable than others to the adverse effects of cannabis is now of paramount importance to public health. Here, we review the current state of knowledge about such vulnerability factors, the variations in types of cannabis, and the relationship between these and cognition and addiction.

Original languageEnglish
Pages (from-to)293-306
Number of pages14
JournalNature Reviews Neuroscience
Issue number5
Early online date7 Apr 2016
Publication statusPublished - May 2016


  • Animals
  • Behavior, Addictive/chemically induced
  • Brain/drug effects
  • Cannabis/adverse effects
  • Case-Control Studies
  • Cognition/drug effects
  • Humans
  • Marijuana Smoking/adverse effects
  • Receptor, Cannabinoid, CB1/metabolism
  • Risk Factors


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