Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-Week races?

A Lucia, F Gomez-Gallego, J L Chicharro, J Hoyos, K Celaya, A Cordova, G Villa, J M Alonso, M Barriopedro, M Perez, Conrad P Earnest

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Abstract

In this paper, we examine the association between polymorphisms of the angiotensin-converting enzyme (ACE) and muscle-specific creatine kinase (CKMM) genes, and the actual performance status observed in professional cyclists capable of completing a classic tour stage race such as the Giro d'Italia, Tour de France, or Vuelta a Espana. To accomplish this, we compared the frequencies of the ACE and CKMM genotypes/alleles in 50 top-level Spanish professional cyclists that have completed at least one of these events to 119 sedentary controls, and 27 elite (Olympic-class) Spanish runners. The genetic polymorphism at the CK-MM locus was detected with the NcoI restriction endonuclease. The results of our study showed that the proportion of the DD genotype was higher in cyclists (50.0 %) than in the other two groups (p < 0.05), the proportion of the ID genotype was higher in controls (46.2 %) than in the other two groups (p < 0.05), and the proportion of the II genotype was higher in runners (40.7 %) than in the other two groups (p < 0.05). The proportion of the D allele was higher in both cyclists (65.0 %) and controls (57.6 %) than in runners (46.3 %) (p < 0.001), whereas the proportion of the I allele was higher in runners than in the other two groups (p < 0.001). No statistical differences were found for CKK-MM- NcoI. We conclude that in top-level professional cyclists capable of completing a classic 3-wk tour race, the frequency distribution of the D allele and the DD genotype seems to be higher than in other endurance athletes such as elite runners (in whom the I allele is especially frequent).
Original languageEnglish
Pages (from-to)442-447
Number of pages6
JournalInternational Journal of Sports Medicine
Volume26
Issue number6
DOIs
Publication statusPublished - 2005

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Peptidyl-Dipeptidase A
Alleles
Genotype
MM Form Creatine Kinase
DNA Restriction Enzymes
Genetic Polymorphisms
Athletes
France
Genes

Cite this

Lucia, A., Gomez-Gallego, F., Chicharro, J. L., Hoyos, J., Celaya, K., Cordova, A., ... Earnest, C. P. (2005). Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-Week races? International Journal of Sports Medicine, 26(6), 442-447. https://doi.org/10.1055/s-2004-821108

Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-Week races? / Lucia, A; Gomez-Gallego, F; Chicharro, J L; Hoyos, J; Celaya, K; Cordova, A; Villa, G; Alonso, J M; Barriopedro, M; Perez, M; Earnest, Conrad P.

In: International Journal of Sports Medicine, Vol. 26, No. 6, 2005, p. 442-447.

Research output: Contribution to journalArticle

Lucia, A, Gomez-Gallego, F, Chicharro, JL, Hoyos, J, Celaya, K, Cordova, A, Villa, G, Alonso, JM, Barriopedro, M, Perez, M & Earnest, CP 2005, 'Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-Week races?', International Journal of Sports Medicine, vol. 26, no. 6, pp. 442-447. https://doi.org/10.1055/s-2004-821108
Lucia, A ; Gomez-Gallego, F ; Chicharro, J L ; Hoyos, J ; Celaya, K ; Cordova, A ; Villa, G ; Alonso, J M ; Barriopedro, M ; Perez, M ; Earnest, Conrad P. / Is there an association between ACE and CKMM polymorphisms and cycling performance status during 3-Week races?. In: International Journal of Sports Medicine. 2005 ; Vol. 26, No. 6. pp. 442-447.
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abstract = "In this paper, we examine the association between polymorphisms of the angiotensin-converting enzyme (ACE) and muscle-specific creatine kinase (CKMM) genes, and the actual performance status observed in professional cyclists capable of completing a classic tour stage race such as the Giro d'Italia, Tour de France, or Vuelta a Espana. To accomplish this, we compared the frequencies of the ACE and CKMM genotypes/alleles in 50 top-level Spanish professional cyclists that have completed at least one of these events to 119 sedentary controls, and 27 elite (Olympic-class) Spanish runners. The genetic polymorphism at the CK-MM locus was detected with the NcoI restriction endonuclease. The results of our study showed that the proportion of the DD genotype was higher in cyclists (50.0 {\%}) than in the other two groups (p < 0.05), the proportion of the ID genotype was higher in controls (46.2 {\%}) than in the other two groups (p < 0.05), and the proportion of the II genotype was higher in runners (40.7 {\%}) than in the other two groups (p < 0.05). The proportion of the D allele was higher in both cyclists (65.0 {\%}) and controls (57.6 {\%}) than in runners (46.3 {\%}) (p < 0.001), whereas the proportion of the I allele was higher in runners than in the other two groups (p < 0.001). No statistical differences were found for CKK-MM- NcoI. We conclude that in top-level professional cyclists capable of completing a classic 3-wk tour race, the frequency distribution of the D allele and the DD genotype seems to be higher than in other endurance athletes such as elite runners (in whom the I allele is especially frequent).",
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AU - Gomez-Gallego, F

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AU - Celaya, K

AU - Cordova, A

AU - Villa, G

AU - Alonso, J M

AU - Barriopedro, M

AU - Perez, M

AU - Earnest, Conrad P

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