Abstract
Herein, we report an iron-catalyzed transfer hydrogenation of allylic alcohols. The operationally simple protocol employs a well-defined bench stable (cyclopentadienone)iron(0) carbonyl complex as a precatalyst in combination with K 2CO 3 (4 mol %) and isopropanol as the hydrogen donor. A diverse range of allylic alcohols undergo transfer hydrogenation to form the corresponding alcohols in good yields (33 examples, ≤83% isolated yield). The scope and limitations of the method have been investigated, and experiments that shed light on the reaction mechanism have been conducted.
| Original language | English |
|---|---|
| Pages (from-to) | 14571-14576 |
| Number of pages | 6 |
| Journal | Journal of Organic Chemistry |
| Volume | 89 |
| Issue number | 19 |
| Early online date | 25 Sept 2024 |
| DOIs | |
| Publication status | Published - 4 Oct 2024 |
Data Availability Statement
The data underlying this study are openly available in the Cardiff University data catalogue at 10.17035/d.2024.0324584208.Acknowledgements
We gratefully acknowledge the School of Chemistry at Cardiff University and the Department of Chemistry at the University of Bath for generous support.Funding
SAE thanks the British Council and the Egyptian Cultural Affairs and Missions Sector for a PhD studentship through the Newton-Mosharafa Fund. TM thanks the Higher Education Commission of Pakistan PostDoctoral Fellowship Programme (Phase III). DEL thanks the EPSRC-funded Bath/Bristol/Cardiff Catalysis Centre for Doctoral Training (EP/L016443/1)