Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach

Kurt Polidano, Benjamin D.W. Allen, Jonathan M.J. Williams, Louis C. Morrill

Research output: Contribution to journalArticlepeer-review

213 Citations (SciVal)


A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).

Original languageEnglish
Pages (from-to)6440-6445
Number of pages6
JournalACS Catalysis
Issue number7
Early online date14 Jun 2018
Publication statusPublished - 6 Jul 2018


  • borrowing hydrogen
  • iron catalysis
  • mechanistic studies
  • methanol
  • methylation

ASJC Scopus subject areas

  • Catalysis


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