Abstract
A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).
Original language | English |
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Pages (from-to) | 6440-6445 |
Number of pages | 6 |
Journal | ACS Catalysis |
Volume | 8 |
Issue number | 7 |
Early online date | 14 Jun 2018 |
DOIs | |
Publication status | Published - 6 Jul 2018 |
Funding
We gratefully acknowledge the School of Chemistry, Cardiff University for generous support, the EPSRC-funded Bath/ Bristol/Cardiff Catalysis Centre for Doctoral Training (K.P., EP/L016443/1), the EPSRC for a standard research grant (B.D.W.A., EP/R006504/1) and the EPSRC UK National Mass Spectrometry Facility at Swansea University.
Keywords
- borrowing hydrogen
- iron catalysis
- mechanistic studies
- methanol
- methylation
ASJC Scopus subject areas
- Catalysis