A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).
|Number of pages||6|
|Early online date||14 Jun 2018|
|Publication status||Published - 6 Jul 2018|
- borrowing hydrogen
- iron catalysis
- mechanistic studies
ASJC Scopus subject areas