Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach

Kurt Polidano, Benjamin D.W. Allen, Jonathan M.J. Williams, Louis C. Morrill

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knölker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).

Original languageEnglish
Pages (from-to)6440-6445
Number of pages6
JournalACS Catalysis
Volume8
Issue number7
Early online date14 Jun 2018
DOIs
Publication statusPublished - 6 Jul 2018

Keywords

  • borrowing hydrogen
  • iron catalysis
  • mechanistic studies
  • methanol
  • methylation

ASJC Scopus subject areas

  • Catalysis

Cite this

Polidano, K., Allen, B. D. W., Williams, J. M. J., & Morrill, L. C. (2018). Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach. ACS Catalysis, 8(7), 6440-6445. https://doi.org/10.1021/acscatal.8b02158