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Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel-Crafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is believed to proceed through a transient acid iodide intermediate.
FingerprintDive into the research topics of 'Iodide as an activating agent for acid chlorides in acylation reactions'. Together they form a unique fingerprint.
- 1 Finished
1/08/11 → 10/05/13
Project: Research council