Iodide as an activating agent for acid chlorides in acylation reactions

R.J. Wakeham, J.E. Taylor, S.D. Bull, J.A. Morris, Jonathan M J Williams

Research output: Contribution to journalArticle

26 Citations (Scopus)


Acid chlorides can be activated using a simple iodide source to undergo nucleophilic attack from a variety of relatively weak nucleophiles. These include Friedel-Crafts acylation of N-methylpyrroles, N-acylation of sulfonamides, and acylation reactions of hindered phenol derivatives. The reaction is believed to proceed through a transient acid iodide intermediate.
Original languageEnglish
Pages (from-to)702-705
Number of pages4
JournalOrganic Letters
Issue number3
Early online date23 Jan 2013
Publication statusPublished - Feb 2013


Cite this