Involvement of the cerebellum in migraine

Mengya Wang; Joseph O. Tutt; Nicholas O. Dorricott; Krystal L. Parker; Andrew F. Russo; Levi P. Sowers

doi:10.3389/fnsys.2022.984406

Involvement of the cerebellum in migraine

Mengya Wang, Joseph O. Tutt, Nicholas O. Dorricott, Krystal L. Parker, Andrew F. Russo, Levi P. Sowers

Research output: Contribution to journal › Review article › peer-review

5 Citations (SciVal)

Abstract

Migraine is a disabling neurological disease characterized by moderate or severe headaches and accompanied by sensory abnormalities, e.g., photophobia, allodynia, and vertigo. It affects approximately 15% of people worldwide. Despite advancements in current migraine therapeutics, mechanisms underlying migraine remain elusive. Within the central nervous system, studies have hinted that the cerebellum may play an important sensory integrative role in migraine. More specifically, the cerebellum has been proposed to modulate pain processing, and imaging studies have revealed cerebellar alterations in migraine patients. This review aims to summarize the clinical and preclinical studies that link the cerebellum to migraine. We will first discuss cerebellar roles in pain modulation, including cerebellar neuronal connections with pain-related brain regions. Next, we will review cerebellar symptoms and cerebellar imaging data in migraine patients. Lastly, we will highlight the possible roles of the neuropeptide calcitonin gene-related peptide (CGRP) in migraine symptoms, including preclinical cerebellar studies in animal models of migraine.

Original language	English
Article number	984406
Journal	Frontiers in Systems Neuroscience
Volume	16
DOIs	https://doi.org/10.3389/fnsys.2022.984406
Publication status	Published - 13 Oct 2022
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (R01 NS075599); VA-ORD (RR&D) MERIT (1 I01 RX003523-0); Career Development Award (IK2 RX002010); and Center for Prevention and Treatment of Visual Loss (VA C6810-C).

Funding Information:
We thank the VA Center for the Prevention and Treatment of Visual Loss for use of facilities. We thank Thomas L. Duong, Agatha M. Greenway, and Brandon J. Rea for writing assistance.

Keywords

cerebellum
CGRP
migraine
pain
sensory processing

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Developmental Neuroscience
Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.3389/fnsys.2022.984406Licence: CC BY

Cite this

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title = "Involvement of the cerebellum in migraine",

abstract = "Migraine is a disabling neurological disease characterized by moderate or severe headaches and accompanied by sensory abnormalities, e.g., photophobia, allodynia, and vertigo. It affects approximately 15% of people worldwide. Despite advancements in current migraine therapeutics, mechanisms underlying migraine remain elusive. Within the central nervous system, studies have hinted that the cerebellum may play an important sensory integrative role in migraine. More specifically, the cerebellum has been proposed to modulate pain processing, and imaging studies have revealed cerebellar alterations in migraine patients. This review aims to summarize the clinical and preclinical studies that link the cerebellum to migraine. We will first discuss cerebellar roles in pain modulation, including cerebellar neuronal connections with pain-related brain regions. Next, we will review cerebellar symptoms and cerebellar imaging data in migraine patients. Lastly, we will highlight the possible roles of the neuropeptide calcitonin gene-related peptide (CGRP) in migraine symptoms, including preclinical cerebellar studies in animal models of migraine.",

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note = "Funding Information: This work was supported by the National Institutes of Health (R01 NS075599); VA-ORD (RR&D) MERIT (1 I01 RX003523-0); Career Development Award (IK2 RX002010); and Center for Prevention and Treatment of Visual Loss (VA C6810-C). Funding Information: We thank the VA Center for the Prevention and Treatment of Visual Loss for use of facilities. We thank Thomas L. Duong, Agatha M. Greenway, and Brandon J. Rea for writing assistance. ",

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AU - Sowers, Levi P.

N1 - Funding Information: This work was supported by the National Institutes of Health (R01 NS075599); VA-ORD (RR&D) MERIT (1 I01 RX003523-0); Career Development Award (IK2 RX002010); and Center for Prevention and Treatment of Visual Loss (VA C6810-C). Funding Information: We thank the VA Center for the Prevention and Treatment of Visual Loss for use of facilities. We thank Thomas L. Duong, Agatha M. Greenway, and Brandon J. Rea for writing assistance.

PY - 2022/10/13

Y1 - 2022/10/13

N2 - Migraine is a disabling neurological disease characterized by moderate or severe headaches and accompanied by sensory abnormalities, e.g., photophobia, allodynia, and vertigo. It affects approximately 15% of people worldwide. Despite advancements in current migraine therapeutics, mechanisms underlying migraine remain elusive. Within the central nervous system, studies have hinted that the cerebellum may play an important sensory integrative role in migraine. More specifically, the cerebellum has been proposed to modulate pain processing, and imaging studies have revealed cerebellar alterations in migraine patients. This review aims to summarize the clinical and preclinical studies that link the cerebellum to migraine. We will first discuss cerebellar roles in pain modulation, including cerebellar neuronal connections with pain-related brain regions. Next, we will review cerebellar symptoms and cerebellar imaging data in migraine patients. Lastly, we will highlight the possible roles of the neuropeptide calcitonin gene-related peptide (CGRP) in migraine symptoms, including preclinical cerebellar studies in animal models of migraine.

AB - Migraine is a disabling neurological disease characterized by moderate or severe headaches and accompanied by sensory abnormalities, e.g., photophobia, allodynia, and vertigo. It affects approximately 15% of people worldwide. Despite advancements in current migraine therapeutics, mechanisms underlying migraine remain elusive. Within the central nervous system, studies have hinted that the cerebellum may play an important sensory integrative role in migraine. More specifically, the cerebellum has been proposed to modulate pain processing, and imaging studies have revealed cerebellar alterations in migraine patients. This review aims to summarize the clinical and preclinical studies that link the cerebellum to migraine. We will first discuss cerebellar roles in pain modulation, including cerebellar neuronal connections with pain-related brain regions. Next, we will review cerebellar symptoms and cerebellar imaging data in migraine patients. Lastly, we will highlight the possible roles of the neuropeptide calcitonin gene-related peptide (CGRP) in migraine symptoms, including preclinical cerebellar studies in animal models of migraine.

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Involvement of the cerebellum in migraine

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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