Abstract
Crystal size and shape can be manipulated to enhance the qualities of the final product. In this work the steady-state shape and size of succinic acid crystals, with and without a polymeric additive (Pluronic P123) at 350 mL, scale is reported. The effect of the amplitude of cycles as well as the heating/cooling rates is described, and convergent cycling (direct nucleation control) is compared to static cycling. The results show that the shape of succinic acid crystals changes from plate- to diamond-like after multiple cycling steps, and that the time required for this morphology change to occur is strongly related to the type of cycling. Addition of the polymer is shown to affect both the final shape of the crystals and the time needed to reach size and shape steady-state conditions. It is shown how this phenomenon can be used to improve the design of the crystallization step in order to achieve more efficient downstream operations and, in general, to help optimize the whole manufacturing process.
Original language | English |
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Pages (from-to) | 1695-1706 |
Number of pages | 12 |
Journal | Crystal Growth and Design |
Volume | 17 |
Issue number | 4 |
Early online date | 9 Mar 2017 |
DOIs | |
Publication status | Published - 5 Apr 2017 |
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- Condensed Matter Physics
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Single Crystal XRD Diffractometer (Excalibur)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment