Intramolecular C-H insertion in ring-expanded N-heterocyclic carbenes

R S Holdroyd, M J Page, M R Warren, M K Whittlesey

Research output: Contribution to journalArticle

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Abstract

Mild heating of the ring-expanded N-heterocyclic Carbenes 7-Mes and 6-Mes results in intramolecular insertion of the carbene into an ortho-methyl C-H bond. In the presence of traces of acid, the resulting products ring-open to afford N-alkyl indoles. (C) 2009 Elsevier Ltd. All rights reserved.
LanguageEnglish
Pages557-559
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number3
DOIs
StatusPublished - Jan 2010

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Indoles
Heating
Acids
carbene

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Intramolecular C-H insertion in ring-expanded N-heterocyclic carbenes. / Holdroyd, R S; Page, M J; Warren, M R; Whittlesey, M K.

In: Tetrahedron Letters, Vol. 51, No. 3, 01.2010, p. 557-559.

Research output: Contribution to journalArticle

Holdroyd, R S ; Page, M J ; Warren, M R ; Whittlesey, M K. / Intramolecular C-H insertion in ring-expanded N-heterocyclic carbenes. In: Tetrahedron Letters. 2010 ; Vol. 51, No. 3. pp. 557-559
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