Intestinal permeation enhancers for oral peptide delivery

Sam Maher, Randall Mrsny, David J. Brayden

Research output: Contribution to journalArticlepeer-review

250 Citations (SciVal)


Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models. In depth analysis of pre-clinical data is presented for PEs as components of proprietary delivery systems that have progressed to clinical trials. Given the importance of co-presentation of sufficiently high concentrations of PE and peptide at the small intestinal epithelium, there is an emphasis on studies where PEs have been formulated with poorly permeable molecules in solid dosage forms and lipoidal dispersions.
Original languageEnglish
Pages (from-to)277-319
JournalAdvanced Drug Delivery Reviews
Issue numberPart B
Publication statusPublished - 15 Nov 2016


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