Interventional laser surgery for oral potentially malignant disorders – a longitudinal patient cohort study

P. J. Thomson, M. L. Goodson, K. Cocks, J. E. Turner

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. In 2011, 6,767 new cases and 2,056 deaths occurred in the UK. Cancers are preceded by oral potentially malignant disorders (PMD), recognizable mucosal diseases harbouring increased, SCC risk offering clinicians a ‘therapeutic window’ to intervene. Contemporary practice remains unable to predict lesion behaviour or quantify malignant transformation (MT) risk. No clear management guidelines exist and the literature cannot determine whether early diagnosis and intervention prevents cancer. 773 laser treatments were performed between 1996 and 2014 in Newcastle Maxillofacial Surgery and efficacy of intervention examined by reviewing clinico-pathological details and clinical outcome for 590 PMD patients followed for a mean of 7.3yrs. Histopathology required ‘up-grading’ in 36% on examining excision specimens. 74.2% of patients were disease free (DF), younger patients with ‘low-grade’ dysplasia, whilst 9% exhibited persistent disease and were older with proliferative verrucous leukoplakia (PVL). DF status was less likely for erythroleukoplakia (p=0.022), ‘high-grade’ dysplasia (p<0.0001) and with lichenoid inflammation (P=0.028). In 12%, unexpected OSCC was identified, whilst 4.8% transformed to malignancy. Interventional laser surgery facilitates definitive diagnosis and treatment, allows early diagnosis of OSCC, identifies progressive disease and defines outcome categories. Evidence is lacking that intervention halts carcinogenesis. Multi-centre, prospective, RCTs are needed to confirm the efficacy of surgery.
Original languageEnglish
Pages (from-to)337-342
JournalInternational Journal of Oral & Maxillofacial surgery
Volume46
Issue number3
Early online date17 Nov 2016
DOIs
Publication statusPublished - Mar 2017

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Laser Therapy
Cohort Studies
Squamous Cell Carcinoma
Early Diagnosis
Leukoplakia
Oral Surgery
Mouth Neoplasms
Neoplasms
Carcinogenesis
Lasers
Therapeutics
Guidelines
Inflammation
Incidence

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Interventional laser surgery for oral potentially malignant disorders – a longitudinal patient cohort study. / Thomson, P. J.; Goodson, M. L.; Cocks, K.; Turner, J. E.

In: International Journal of Oral & Maxillofacial surgery, Vol. 46, No. 3, 03.2017, p. 337-342.

Research output: Contribution to journalArticle

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