Interval training in men at risk for insulin resistance

C. P. Earnest, M. Lupo, J. Thibodeaux, C. Hollier, B. Butitta, E. Lejeune, N. M. Johannsen, M. J. Gibala, T. S. Church

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45 Citations (SciVal)


We compared 3 months of eucaloric (12 kcal/kg/wk) steady state aerobic training (AER) to interval training (INT) in men at risk for insulin resistance. Primary outcomes included oral glucose tolerance testing (OGTT) and HOMA-IR 24 h and 72 h after each participants last exercise session. Secondary outcomes were VO 2max, anthropometry, and metabolic syndrome expressed as a summed z-score (zMS). We also performed a sub-analysis for participants entering the trial above and below the HOMA-IR study median. Mean (95% CI) AER (- 12.81 mg/dl; - 24.7, - 1.0) and INT (- 14.26 mg/dl; - 24.9, - 3.6) significantly improved 24 h OGTT. HOMA-IR did not improve for AER, but did for INT 24 h and 72 h post-exercise. VO 2max improved similarly for both groups. Changes in body mass for INT (- 2.29 kg; - 3.51, - 1.14), AER, (- 1.32 kg; - 2.62, 0.58)] and percent body fat [INT, - 0.83%; - 1.62, - 0.03), AER (- 0.17%; - 1.07, 0.06)] were only significant for INT. When examined as a full cohort, zMS improved for both groups. Upon HOMA-IR stratification, only high HOMA-IR AER showed significant improvements, while both low and high INT HOMA-IR participants demonstrated significant reductions (P<0.05). Eucaloric AER and INT appear to affect fasting glucose, OGTT and VO 2max similarly, while INT may have a greater impact on HOMA-IR and zMS.
Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalInternational Journal of Sports Medicine
Issue number4
Publication statusPublished - 2013


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