Interspecies recombination In nature: a meningococcus that has acquired a gonococcal PIB porin

Julio A‐ Vázquez, Sonsoles Berron, Maria O'Rourke, Gill Carpenter, Edward Feil, Noel H. Smith, Brian G. Spratt

Research output: Contribution to journalArticlepeer-review


A. vaginal isolate of Neisseria has been reported to resemble Neisseria meningitidis in biochemical characteristics but to react with serological reagents that are specific to the PI porin from Neisseria gonorrhoeae. We have confirmed that this isolate has the biochemical attributes of a meningococcus and have shown that it clusters among meningococcal Isolates on a dendrogram based on isoenzyme variation within housekeeping enzymes from populations of N. meningitidis and N. gonorrhoeae. Furthermore, the sequences of the fbp and adk genes were typical of those of N. meningitidis and were distinct from those of N. gonorrhoeae. However, the porB gene was very similar to the por genes of N. gonorrhoeae isolates that express the PIB class of outer‐membrane porin (differing from one gonococcal por allele at only a single nucleotide site), and was clearly distinct from the porB genes of N. meningitidis. The isolate therefore appears to be a typical meningococcus, except that its porB gene has been replaced with the por gene from a gonococcus.

Original languageEnglish
Pages (from-to)1001-1007
Number of pages7
JournalMolecular Microbiology
Issue number6
Publication statusPublished - 31 Mar 1995

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


Dive into the research topics of 'Interspecies recombination In nature: a meningococcus that has acquired a gonococcal PIB porin'. Together they form a unique fingerprint.

Cite this