Interrupting Prolonged Sitting with Intermittent Walking Increases Postprandial Gut Hormone Responses

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Abstract

Introduction Continuous exercise can increase postprandial gut hormone such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) responses, but it is unknown whether interrupting prolonged sitting with intermittent walking elicits this effect. Method Ten participants with central overweight/obesity (7 men and 3 postmenopausal women, 51 ± 5 yr; mean ± SD) completed a randomized crossover study in which they consumed breakfast and lunch in the laboratory while either sitting continuously for the entire 5.5-h period (SIT) or the prolonged sitting interrupted every 20 min by walking briskly (6.4 km·h-1) for 2 min (BREAKS). Blood samples were collected at regular intervals to examine postprandial plasma GLP-1, PYY, and glucose-dependent insulinotropic polypeptide concentrations. Adipose tissue samples were collected at baseline and at the end of the trials to examine changes in net dipeptidyl peptidase 4 secretion from primary explants. Results Mean (95% confidence interval) postprandial GLP-1 and PYY incremental area under curve values were elevated by 26% and 31% in the BREAKS trial versus SIT (8.4 [0.7, 16.1] vs 6.7 [-0.8, 14.2], P = 0.001, and 26.9 [8.1, 45.6] vs 20.4 [5.1, 35.8] nmol·330 min·L-1, P = 0.024, respectively) but without any such effect on glucose-dependent insulinotropic polypeptide (P = 0.076) or net adipose tissue dipeptidyl peptidase 4 secretion (P > 0.05). Conclusions Interrupting prolonged sitting with regular short bouts of brisk walking increases postprandial GLP-1 and PYY concentrations in healthy middle-age men and women with central adiposity.

Original languageEnglish
Pages (from-to)1183-1189
Number of pages7
JournalMedicine & Science in Sports & Exercise
Volume54
Issue number7
Early online date6 Apr 2022
DOIs
Publication statusPublished - 31 Jul 2022

Bibliographical note

Funding Information:
Y. C. C. was responsible funding, study design and conduct, data collection, data analysis, data interpretation, statistical analysis, draft written, and manuscript revision. J. A. B. was responsible for study design and manuscript revision. J. P. W., A. H., and J. T. G. assisted with technical support and manuscript revision. D.T. was responsible for funding, study design, data interpretation, and manuscript revision.

Funding Information:
This project was partly funded by National Taiwan Normal University and Ministry of Science and Technology (MOST 109-2410-H-003-068) and the University of Bath. The authors thank all the participants for their time and effort to take part in this project.

Publisher Copyright:
© Lippincott Williams & Wilkins.

Keywords

  • GLUCAGON-LIKE PEPTIDE 1
  • GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE
  • INCRETIN
  • PEPTIDE YY
  • PROLONGED SITTING
  • SEDENTARY

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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