TY - JOUR
T1 - Interpretation and prediction of the kinetics of transdermal drug delivery
T2 - oestradiol, hyoscine and timolol
AU - Guy, Richard H.
AU - Hadgraft, Jonathan
N1 - Funding Information:
Financial support was received from NIH (GM-33395) and Vick International. R.H.G. is the recipient of a Special Emphasis Research Career Award from the National Institute of Occupational Safety and Health (KOl-OH-00017).
PY - 1986/10/31
Y1 - 1986/10/31
N2 - A kinetic model has been used to predict the plasma concentration vs time profiles for oestradiol, hyoscine and timolol following transdermal drug delivery. Rate constants describing a drug's passage across the stratum corneum and viable epidermis are calculated from simple physicochemical parameters. When used in conjunction with the in vitro release characteristics of the topical formulation (simple vehicle or sophisticated delivery system), and with knowledge of the drug's systemic clearance, the kinetic values permit simulation of the expected plasma level profile. The theoretical predictions are consistent with published human in vivo data for each of the three compounds. This kinetic approach may be useful, therefore, in the evaluation of feasible candidates for transdermal drug delivery.
AB - A kinetic model has been used to predict the plasma concentration vs time profiles for oestradiol, hyoscine and timolol following transdermal drug delivery. Rate constants describing a drug's passage across the stratum corneum and viable epidermis are calculated from simple physicochemical parameters. When used in conjunction with the in vitro release characteristics of the topical formulation (simple vehicle or sophisticated delivery system), and with knowledge of the drug's systemic clearance, the kinetic values permit simulation of the expected plasma level profile. The theoretical predictions are consistent with published human in vivo data for each of the three compounds. This kinetic approach may be useful, therefore, in the evaluation of feasible candidates for transdermal drug delivery.
KW - transdermal drug delivery - oestradiol - hyoscine - timolol
UR - http://www.scopus.com/inward/record.url?scp=0022500082&partnerID=8YFLogxK
U2 - 10.1016/0378-5173(86)90174-2
DO - 10.1016/0378-5173(86)90174-2
M3 - Article
AN - SCOPUS:0022500082
VL - 32
SP - 159
EP - 163
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 2-3
ER -