Interpolymer Complexes of Eudragit ® Copolymers as Novel Carriers for Colon-Specific Drug Delivery

Aleksandra V Bukhovets, Nikoletta Fotaki, Vitaliy V Khutoryanskiy , Rouslan I Moustafine

Research output: Contribution to journalArticle

Abstract

Interpolymer complexes (IPC) based on Eudragit® EPO and Eudragit® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit® S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid).
Original languageEnglish
Article number1459
Pages (from-to)1-16
Number of pages16
JournalPolymers
Volume12
Issue number7
DOIs
Publication statusPublished - 30 Jun 2020

Keywords

  • Biorelevant media
  • Controlled drug delivery
  • Drug delivery systems
  • Eudragit
  • Indomethacin
  • Interpolymer complexes
  • Oral drug delivery

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

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