Abstract
Interpolymer complexes (IPC) based on Eudragit® EPO and Eudragit® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit® S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid).
Original language | English |
---|---|
Article number | 1459 |
Pages (from-to) | 1-16 |
Number of pages | 16 |
Journal | Polymers |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Published - 30 Jun 2020 |
Keywords
- Biorelevant media
- Controlled drug delivery
- Drug delivery systems
- Eudragit
- Indomethacin
- Interpolymer complexes
- Oral drug delivery
ASJC Scopus subject areas
- General Chemistry
- Polymers and Plastics
Fingerprint
Dive into the research topics of 'Interpolymer Complexes of Eudragit ® Copolymers as Novel Carriers for Colon-Specific Drug Delivery'. Together they form a unique fingerprint.Equipment
-
Differential Scanning Calorimeter (DSC)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment
-
HR-2 Discovery Hybrid Rheometer
Department of Architecture & Civil EngineeringFacility/equipment: Equipment