Intercross

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The word intercross refers to a multistep process used to create an experimental population that mixes the genomes from a set of two or more progenitor ('parental') genotypes. There are many schemes that can be used to produce an intercross population, though most often a single pair of progenitors is used to produce a pairwise cross. The resulting intercross populations contain chromosomes and genomes that are mixtures of the parental genotypes. Intercross populations are most often used for mapping studies, but may also be used for other quantitative genetic or experimental analyses. They are useful in mapping studies because, if the parental genotypes differ for some traits of interest, the intercross population will have variation for those traits segregating among genotypes. Loci can, therefore, be mapped by identifying chromosomal blocks derived from the different parental genotypes and testing their association with the traits of interest. In many experimental systems, the intercross population is inbred to create a set of recombinant inbred lines, which allow one to use the same set of 'immortal' genotypes in a series of experiments without the need to recreate the intercross or, in most cases, to genotype the individuals you are studying.

Original languageEnglish
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier
Pages115-117
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
Publication statusPublished - 31 Dec 2013

Keywords

  • Advanced intercross line
  • Association mapping
  • Experimental populations
  • Fine mapping
  • Gene mapping
  • Multiparent advanced generation intercross (MAGIC) lines
  • QTL analysis
  • Recombinant inbred line
  • Transgressive segregation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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