Abstract
The word intercross refers to a multistep process used to create an experimental population that mixes the genomes from a set of two or more progenitor ('parental') genotypes. There are many schemes that can be used to produce an intercross population, though most often a single pair of progenitors is used to produce a pairwise cross. The resulting intercross populations contain chromosomes and genomes that are mixtures of the parental genotypes. Intercross populations are most often used for mapping studies, but may also be used for other quantitative genetic or experimental analyses. They are useful in mapping studies because, if the parental genotypes differ for some traits of interest, the intercross population will have variation for those traits segregating among genotypes. Loci can, therefore, be mapped by identifying chromosomal blocks derived from the different parental genotypes and testing their association with the traits of interest. In many experimental systems, the intercross population is inbred to create a set of recombinant inbred lines, which allow one to use the same set of 'immortal' genotypes in a series of experiments without the need to recreate the intercross or, in most cases, to genotype the individuals you are studying.
| Original language | English |
|---|---|
| Title of host publication | Brenner's Encyclopedia of Genetics (2nd ed.) |
| Publisher | Elsevier |
| Pages | 115-117 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780080961569 |
| ISBN (Print) | 9780123749840 |
| DOIs | |
| Publication status | Published - 31 Dec 2013 |
Keywords
- Advanced intercross line
- Association mapping
- Experimental populations
- Fine mapping
- Gene mapping
- Multiparent advanced generation intercross (MAGIC) lines
- QTL analysis
- Recombinant inbred line
- Transgressive segregation
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry,Genetics and Molecular Biology
- General Medicine