Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study.

H Chinoy, S Adimulam, F Marriage, P New, M Vincze, E Zilahi, A Kapitány, A Gyetvai, L Ekholm, P Novota, M Remakova, P Charles, Neil J McHugh, L Padyukov, L Alfredsson, J Vencovsky, I E Lundberg, K Danko, W E Ollier, R G Cooper

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66 Citations (Scopus)

Abstract

OBJECTIVES: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM.METHODS: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation.RESULTS: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1-positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p
Original languageEnglish
Pages (from-to)961-965
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume71
Issue number6
Early online date20 Dec 2011
DOIs
Publication statusPublished - Jun 2012

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