Integrating muscle cell biochemistry and whole-body physiology in humans: 31P-MRS data from the InSight trial and their correlates

L. M. Edwards, G. J. Kemp, R. M. Dwyer, J. T. Walls, H. Fuller, S. R. Smith, C. P. Earnest

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Abstract

We acquired 31P-MRS data from skeletal muscle of subjects of mixed gender and ethnicity, combined with a panel of physiological characteristics, and tested several long-standing hypotheses regarding relationships between muscle cell biochemistry and whole-body physiology with unusually high statistical power. We hypothesized that i) whole-body VO2max would correlate with muscle respiratory capacity, ii) resting muscle phosphocreatine concentration ([PCr]) would negatively correlate with delta efficiency and iii) muscle mitochondrial function would positively correlate with both resting VO2 and total daily energy expenditure (TDEE). Muscle respiratory capacity explained a quarter of the variation in VO2max (r2 = 26, p < .001, n = 87). There was an inverse correlation between muscle [PCr] and delta efficiency (r = −23, p = 046, n = 87). There was also a correlation between [PCr] recovery halftime and TDEE (r = −23, p = 035, n = 87). Our data not only provide insights into muscle cell chemistry and whole-body physiology but our mixed cohort means that our findings are broadly generalizable.
Original languageEnglish
Article number1182
Number of pages7
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 31 Jan 2013

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