Integrated plug flow synthesis and crystallisation of pyrazinamide

Christopher Scott, Ricardo Labes, Martin Depardieu, Claudio Battilocchio, Matthew Davidson, Steven Ley, Charles Wilson, Karen Robertson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.
Original languageEnglish
Pages (from-to)631-634
Number of pages4
JournalReaction Chemistry & Engineering
Volume3
Issue number5
Early online date10 Jul 2018
DOIs
Publication statusPublished - 1 Oct 2018

Fingerprint

Pyrazinamide
Crystallization
Packed beds
Hydration
Effluents

Keywords

  • Flow Chemistry
  • Crystallisation
  • Continuous crystallisation

Cite this

Integrated plug flow synthesis and crystallisation of pyrazinamide. / Scott, Christopher; Labes, Ricardo; Depardieu, Martin; Battilocchio, Claudio; Davidson, Matthew; Ley, Steven; Wilson, Charles; Robertson, Karen.

In: Reaction Chemistry & Engineering, Vol. 3, No. 5, 01.10.2018, p. 631-634.

Research output: Contribution to journalArticle

Scott, Christopher ; Labes, Ricardo ; Depardieu, Martin ; Battilocchio, Claudio ; Davidson, Matthew ; Ley, Steven ; Wilson, Charles ; Robertson, Karen. / Integrated plug flow synthesis and crystallisation of pyrazinamide. In: Reaction Chemistry & Engineering. 2018 ; Vol. 3, No. 5. pp. 631-634.
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