We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.
- Flow Chemistry
- Continuous crystallisation
Scott, C. D., Labes, R., Depardieu, M., Battilocchio, C., Davidson, M., Ley, S., ... Robertson, K. (2018). Integrated plug flow synthesis and crystallisation of pyrazinamide. Reaction Chemistry & Engineering, 3(5), 631-634. https://doi.org/10.1039/C8RE00087E