Integrated plug flow synthesis and crystallisation of pyrazinamide

C. Daniel Scott, Ricardo Labes, Martin Depardieu, Claudio Battilocchio, Matthew Davidson, Steven Ley, Charles Wilson, Karen Robertson

Research output: Contribution to journalArticlepeer-review

20 Citations (SciVal)


We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.
Original languageEnglish
Pages (from-to)631-634
Number of pages4
JournalReaction Chemistry & Engineering
Issue number5
Early online date10 Jul 2018
Publication statusPublished - 1 Oct 2018


  • Flow Chemistry
  • Crystallisation
  • Continuous crystallisation


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