Integrated plug flow synthesis and crystallisation of pyrazinamide

C. Daniel Scott; Ricardo Labes; Martin Depardieu; Claudio Battilocchio; Matthew Davidson; Steven Ley; Charles Wilson; Karen Robertson

doi:10.1039/C8RE00087E

Integrated plug flow synthesis and crystallisation of pyrazinamide

C. Daniel Scott, Ricardo Labes, Martin Depardieu, Claudio Battilocchio, Matthew Davidson, Steven Ley, Charles Wilson, Karen Robertson

University of Cambridge

Research output: Contribution to journal › Article › peer-review

22 Citations (SciVal)

Abstract

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

Original language	English
Pages (from-to)	631-634
Number of pages	4
Journal	Reaction Chemistry & Engineering
Volume	3
Issue number	5
Early online date	10 Jul 2018
DOIs	https://doi.org/10.1039/C8RE00087E
Publication status	Published - 1 Oct 2018

Keywords

Flow Chemistry
Crystallisation
Continuous crystallisation

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AU - Labes, Ricardo

AU - Depardieu, Martin

AU - Battilocchio, Claudio

AU - Davidson, Matthew

AU - Ley, Steven

AU - Wilson, Charles

AU - Robertson, Karen

PY - 2018/10/1

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AB - We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

KW - Flow Chemistry

KW - Crystallisation

KW - Continuous crystallisation

U2 - 10.1039/C8RE00087E

DO - 10.1039/C8RE00087E

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Integrated plug flow synthesis and crystallisation of pyrazinamide

Abstract

Keywords

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