Innate immunity in host-microbial interactions: Beyond B27 in the spondyloarthropathies

C Pacheco-Tena, X Zhang, M Stone, R Burgos-Vargas, R D Inman

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The spondyloarthropathies are diseases influenced by genetic predisposition and, to a varying extent, infectious triggers. A causal role for bacterial infections is most clear for reactive arthritis. Recent insights into arthritogenic components of bacteria may set the stage for a better understanding of disease pathogenesis, the role of heat shock proteins in antigen processing and immune activation, and the adjuvant effect of CpG-DNA. Recent developments in the area of innate immunity broaden current concepts of genetically defined factors in host-pathogen interactions. In particular, the biology of toll-like receptors as important elements in the innate immune response to pathogens is being defined. These factors in innate immunity may have important implications for sequelae of infections, such as reactive arthritis. (C) 2002 Lippincott Williams Wilkins, Inc.
Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalCurrent Opinion in Rheumatology
Volume14
Issue number4
DOIs
Publication statusPublished - 2002

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