Inhibition of hamster sperm Na+, K+-ATPase activity by taurine and hypotaurine

Randall J. Mrsny, Stanley Meizel

Research output: Contribution to journalArticlepeer-review

Abstract

Taurine, hypotaurine and the structural analogue, beta-alanine, were tested for their effects on Na+, K+-ATPase activity of crude homogenates prepared from washed cauda epididymal hamster sperm. Preincubation with 0.1-10 mM taurine or hypotaurine inhibited Na+, K+-ATPase in a dose-dependent manner, while beta-alanine had an inhibitory effect only at 10 mM. The results of this study are the first evidence to demonstrate inhibition of Na+, K+-ATPase activity by taurine and hypotaurine and are discussed in relation to the ability of these compounds to sustain hamster sperm motility and fertility.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalLife Sciences
Volume36
Issue number3
DOIs
Publication statusPublished - 21 Jan 1985

Funding

The authors wish to thank Dr. Peter Cala~ Dr. David Katz and Dr. Peter Working for helpful discussions. This work was supported by National Institute of Health (NIH) grant HD-06698. Randall J. Mrsny was the recipient of an NIH reproductive biology training grant predoctoral fellowship.

FundersFunder number
National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentR01HD006698

    ASJC Scopus subject areas

    • General Biochemistry,Genetics and Molecular Biology
    • Pharmacology, Toxicology and Pharmaceutics(all)

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