Abstract
Taurine, hypotaurine and the structural analogue, beta-alanine, were tested for their effects on Na+, K+-ATPase activity of crude homogenates prepared from washed cauda epididymal hamster sperm. Preincubation with 0.1-10 mM taurine or hypotaurine inhibited Na+, K+-ATPase in a dose-dependent manner, while beta-alanine had an inhibitory effect only at 10 mM. The results of this study are the first evidence to demonstrate inhibition of Na+, K+-ATPase activity by taurine and hypotaurine and are discussed in relation to the ability of these compounds to sustain hamster sperm motility and fertility.
Original language | English |
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Pages (from-to) | 271-275 |
Number of pages | 5 |
Journal | Life Sciences |
Volume | 36 |
Issue number | 3 |
DOIs | |
Publication status | Published - 21 Jan 1985 |
Funding
The authors wish to thank Dr. Peter Cala~ Dr. David Katz and Dr. Peter Working for helpful discussions. This work was supported by National Institute of Health (NIH) grant HD-06698. Randall J. Mrsny was the recipient of an NIH reproductive biology training grant predoctoral fellowship.
Funders | Funder number |
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National Institutes of Health | |
Eunice Kennedy Shriver National Institute of Child Health and Human Development | R01HD006698 |
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology
- Pharmacology, Toxicology and Pharmaceutics(all)