Abstract
A clinical intervention known as 'bridging to transplant', in which a patient is placed on life-sustaining support, can be used to increase the chance of an individual surviving until a donor heart becomes available. However, the impact of this on other patients on the waiting list and the wider implications for the resourcing of cardiac units remains unclear. Initial insights have previously been generated using a birth-death queuing model, but this model did not incorporate realistic donor-recipient assumptions regarding blood type and weight. Here we report on a complementary simulation study that examined how estimates from the analytical model might change if organ matching were better taken into account. Simulation results showed that system metrics changed substantially when recipient donor compatibility was modelled. However, the effects of blood type compatibility were countered by that of weight compatibility and when combined, these have a relatively small net effect on results.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the 2015 Winter Simulation Conference |
| Place of Publication | Piscataway, U. S. A. |
| Publisher | IEEE |
| Pages | 1654-1665 |
| Number of pages | 12 |
| ISBN (Print) | 9781467397421 |
| DOIs | |
| Publication status | Published - 16 Feb 2016 |
| Event | Winter Simulation Conference, WSC 2015 - Huntington Beach, USA United States Duration: 6 Dec 2015 → 9 Dec 2015 |
Conference
| Conference | Winter Simulation Conference, WSC 2015 |
|---|---|
| Country | USA United States |
| City | Huntington Beach |
| Period | 6/12/15 → 9/12/15 |
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Informing the management of pediatric heart transplant waiting lists : complementary use of simulation and analytical modeling. / Crowe, Sonya; Vasilakis, Christos; Gallivan, Steve; Bull, Catherine; Fenton, Matthew.
Proceedings of the 2015 Winter Simulation Conference. Piscataway, U. S. A. : IEEE, 2016. p. 1654-1665 7408285.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Informing the management of pediatric heart transplant waiting lists
T2 - complementary use of simulation and analytical modeling
AU - Crowe, Sonya
AU - Vasilakis, Christos
AU - Gallivan, Steve
AU - Bull, Catherine
AU - Fenton, Matthew
PY - 2016/2/16
Y1 - 2016/2/16
N2 - A clinical intervention known as 'bridging to transplant', in which a patient is placed on life-sustaining support, can be used to increase the chance of an individual surviving until a donor heart becomes available. However, the impact of this on other patients on the waiting list and the wider implications for the resourcing of cardiac units remains unclear. Initial insights have previously been generated using a birth-death queuing model, but this model did not incorporate realistic donor-recipient assumptions regarding blood type and weight. Here we report on a complementary simulation study that examined how estimates from the analytical model might change if organ matching were better taken into account. Simulation results showed that system metrics changed substantially when recipient donor compatibility was modelled. However, the effects of blood type compatibility were countered by that of weight compatibility and when combined, these have a relatively small net effect on results.
AB - A clinical intervention known as 'bridging to transplant', in which a patient is placed on life-sustaining support, can be used to increase the chance of an individual surviving until a donor heart becomes available. However, the impact of this on other patients on the waiting list and the wider implications for the resourcing of cardiac units remains unclear. Initial insights have previously been generated using a birth-death queuing model, but this model did not incorporate realistic donor-recipient assumptions regarding blood type and weight. Here we report on a complementary simulation study that examined how estimates from the analytical model might change if organ matching were better taken into account. Simulation results showed that system metrics changed substantially when recipient donor compatibility was modelled. However, the effects of blood type compatibility were countered by that of weight compatibility and when combined, these have a relatively small net effect on results.
UR - http://dx.doi.org/10.1109/WSC.2015.7408285
UR - http://www.scopus.com/inward/record.url?scp=84962863009&partnerID=8YFLogxK
U2 - 10.1109/WSC.2015.7408285
DO - 10.1109/WSC.2015.7408285
M3 - Chapter
SN - 9781467397421
SP - 1654
EP - 1665
BT - Proceedings of the 2015 Winter Simulation Conference
PB - IEEE
CY - Piscataway, U. S. A.
ER -