Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging

Emma M. TInney, Psyche Loui, Lauren B . Raine, Lucy V. Hiscox, Peyton L . Delgorio, Mary K. Kramer, Hillary Schwarb, Christopher R. Martens, Arthur F. Kramer, Charles H Hillman, Curtis L. Johnson

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Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. To assess whether white matter (WM) integrity is compromised in MCI, we collected diffusion-weighted images from 60 healthy older adults (OA) (69.16±0.7) and 20 older adults with amnestic MCI (72.45±1.9). WM integrity differences were examined using Tract-Based Spatial Statistics (TBSS). We hypothesized that those with MCI would have diminished WM integrity relative to OA. In a whole-brain comparison, those with MCI showed higher axial diffusivity in the splenium (SCC) and body of the corpus callosum (BCC), superior corona radiata (SCR), and the retro-lenticular part of the internal capsule (RLIC) (p’s
Original languageEnglish
Article numbere14306
Number of pages15
Issue number9
Early online date11 Apr 2023
Publication statusPublished - 30 Sept 2023
Externally publishedYes

Bibliographical note

This research was supported in part by grant from the National Institutes of Health (R01-19 AG058853, K01-AG054731). Participant recruitment was supported by the Delaware Center for 20 Cognitive Aging Research.

Data Availability
Data and code is available upon request from corresponding author.


  • aging
  • body mass index
  • diffusion tensor imaging
  • mild cognitive impairment
  • relational memory
  • white matter integrity

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)
  • Physiology


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