Abstract
Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. To assess whether white matter (WM) integrity is compromised in MCI, we collected diffusion-weighted images from 60 healthy older adults (OA) (69.16±0.7) and 20 older adults with amnestic MCI (72.45±1.9). WM integrity differences were examined using Tract-Based Spatial Statistics (TBSS). We hypothesized that those with MCI would have diminished WM integrity relative to OA. In a whole-brain comparison, those with MCI showed higher axial diffusivity in the splenium (SCC) and body of the corpus callosum (BCC), superior corona radiata (SCR), and the retro-lenticular part of the internal capsule (RLIC) (p’s
Original language | English |
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Article number | e14306 |
Number of pages | 15 |
Journal | Psychophysiology |
Volume | 60 |
Issue number | 9 |
Early online date | 11 Apr 2023 |
DOIs | |
Publication status | Published - 30 Sept 2023 |
Externally published | Yes |
Bibliographical note
This research was supported in part by grant from the National Institutes of Health (R01-19 AG058853, K01-AG054731). Participant recruitment was supported by the Delaware Center for 20 Cognitive Aging Research.Data Availability
Data and code is available upon request from corresponding author.
Funding
This research was supported in part by grant from the National Institutes of Health (R01‐AG058853, K01‐AG054731). Participant recruitment was supported by the Delaware Center for Cognitive Aging Research.
Keywords
- aging
- body mass index
- diffusion tensor imaging
- mild cognitive impairment
- relational memory
- white matter integrity
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Neuropsychology and Physiological Psychology
- Physiology (medical)
- Physiology