Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging

Emma M.  TInney; Psyche  Loui; Lauren B . Raine; Lucy V. Hiscox; Peyton L . Delgorio; Mary K. Kramer; Hillary Schwarb; Christopher R. Martens; Arthur F. Kramer; Charles H Hillman; Curtis L.  Johnson

doi:10.1111/psyp.14306

Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging

Emma M. TInney, Psyche Loui, Lauren B . Raine, Lucy V. Hiscox, Peyton L . Delgorio, Mary K. Kramer, Hillary Schwarb, Christopher R. Martens, Arthur F. Kramer, Charles H Hillman, Curtis L. Johnson

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Abstract

Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. To assess whether white matter (WM) integrity is compromised in MCI, we collected diffusion-weighted images from 60 healthy older adults (OA) (69.16±0.7) and 20 older adults with amnestic MCI (72.45±1.9). WM integrity differences were examined using Tract-Based Spatial Statistics (TBSS). We hypothesized that those with MCI would have diminished WM integrity relative to OA. In a whole-brain comparison, those with MCI showed higher axial diffusivity in the splenium (SCC) and body of the corpus callosum (BCC), superior corona radiata (SCR), and the retro-lenticular part of the internal capsule (RLIC) (p’s

Original language	English
Article number	e14306
Number of pages	15
Journal	Psychophysiology
Volume	60
Issue number	9
Early online date	11 Apr 2023
DOIs	https://doi.org/10.1111/psyp.14306
Publication status	Published - 30 Sept 2023
Externally published	Yes

Bibliographical note

This research was supported in part by grant from the National Institutes of Health (R01-19 AG058853, K01-AG054731). Participant recruitment was supported by the Delaware Center for 20 Cognitive Aging Research.

Data Availability
Data and code is available upon request from corresponding author.

Funding

This research was supported in part by grant from the National Institutes of Health (R01‐AG058853, K01‐AG054731). Participant recruitment was supported by the Delaware Center for Cognitive Aging Research.

Keywords

aging
body mass index
diffusion tensor imaging
mild cognitive impairment
relational memory
white matter integrity

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Neuropsychology and Physiological Psychology
Physiology (medical)
Physiology

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10.1111/psyp.14306

Cite this

TInney, E. M., Loui, P., Raine, L. B. ., Hiscox, L. V., Delgorio, P. L. ., Kramer, M. K., Schwarb, H., Martens, C. R., Kramer, A. F., Hillman, C. H., & Johnson, C. L. (2023). Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging. Psychophysiology, 60(9), Article e14306. https://doi.org/10.1111/psyp.14306

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title = "Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging",

abstract = "Mild cognitive impairment (MCI), a prodromal stage of Alzheimer{\textquoteright}s disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. To assess whether white matter (WM) integrity is compromised in MCI, we collected diffusion-weighted images from 60 healthy older adults (OA) (69.16±0.7) and 20 older adults with amnestic MCI (72.45±1.9). WM integrity differences were examined using Tract-Based Spatial Statistics (TBSS). We hypothesized that those with MCI would have diminished WM integrity relative to OA. In a whole-brain comparison, those with MCI showed higher axial diffusivity in the splenium (SCC) and body of the corpus callosum (BCC), superior corona radiata (SCR), and the retro-lenticular part of the internal capsule (RLIC) (p{\textquoteright}s",

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note = "This research was supported in part by grant from the National Institutes of Health (R01-19 AG058853, K01-AG054731). Participant recruitment was supported by the Delaware Center for 20 Cognitive Aging Research. Data Availability Data and code is available upon request from corresponding author.",

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AU - Kramer, Mary K.

AU - Schwarb, Hillary

AU - Martens, Christopher R.

AU - Kramer, Arthur F.

AU - Hillman, Charles H

AU - Johnson, Curtis L.

N1 - This research was supported in part by grant from the National Institutes of Health (R01-19 AG058853, K01-AG054731). Participant recruitment was supported by the Delaware Center for 20 Cognitive Aging Research. Data Availability Data and code is available upon request from corresponding author.

PY - 2023/9/30

Y1 - 2023/9/30

N2 - Mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease, is characterized by decreased memory and cognition, which are linked to degenerative changes in the brain. To assess whether white matter (WM) integrity is compromised in MCI, we collected diffusion-weighted images from 60 healthy older adults (OA) (69.16±0.7) and 20 older adults with amnestic MCI (72.45±1.9). WM integrity differences were examined using Tract-Based Spatial Statistics (TBSS). We hypothesized that those with MCI would have diminished WM integrity relative to OA. In a whole-brain comparison, those with MCI showed higher axial diffusivity in the splenium (SCC) and body of the corpus callosum (BCC), superior corona radiata (SCR), and the retro-lenticular part of the internal capsule (RLIC) (p’s

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Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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