Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels

N. García González; I. W. Kellaway; H. Blanco Fuente; S. Anguiano Igea; B. Delgado Charro; F. J. Otero Espinar; J. Blanco Méndez

doi:10.1016/0378-5173(94)90185-6

Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels

N. García González, I. W. Kellaway, H. Blanco Fuente, S. Anguiano Igea, B. Delgado Charro, F. J. Otero Espinar, J. Blanco Méndez

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The formulation of glycerol-crosslinked Carbopol 907 and Carbopol 941 metoclopramide hydrogels for buccal administration were investigated. Infrared spectroscopy showed that crosslinking was the result of ester formation between Carbopol carboxyl groups and glycerol hydroxyl groups. The effects of Carbopol molecular weight and glycerol concentration on swelling and drug release characteristics were evaluated. In all glycerol-containing formulations drug dissolution efficiencies were low, and both dissolution efficiency and swelling rate decreased with increasing glycerol concentration, confirming the very high crosslinking capacity of glycerol.

Original language	English
Pages (from-to)	107-113
Number of pages	7
Journal	International Journal of Pharmaceutics
Volume	104
Issue number	2
DOIs	https://doi.org/10.1016/0378-5173(94)90185-6
Publication status	Published - 11 Apr 1994

Keywords

Bioadhesion
Carbopol
Crosslinking
Dissolution
Glycerol
Hydrogel
Metoclopramide
Swelling

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10.1016/0378-5173(94)90185-6

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García González, N., Kellaway, I. W., Blanco Fuente, H., Anguiano Igea, S., Delgado Charro, B., Otero Espinar, F. J., & Blanco Méndez, J. (1994). Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels. International Journal of Pharmaceutics, 104(2), 107-113. https://doi.org/10.1016/0378-5173(94)90185-6

García González, N, Kellaway, IW, Blanco Fuente, H, Anguiano Igea, S, Delgado Charro, B, Otero Espinar, FJ & Blanco Méndez, J 1994, 'Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels', International Journal of Pharmaceutics, vol. 104, no. 2, pp. 107-113. https://doi.org/10.1016/0378-5173(94)90185-6

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title = "Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels",

abstract = "The formulation of glycerol-crosslinked Carbopol 907 and Carbopol 941 metoclopramide hydrogels for buccal administration were investigated. Infrared spectroscopy showed that crosslinking was the result of ester formation between Carbopol carboxyl groups and glycerol hydroxyl groups. The effects of Carbopol molecular weight and glycerol concentration on swelling and drug release characteristics were evaluated. In all glycerol-containing formulations drug dissolution efficiencies were low, and both dissolution efficiency and swelling rate decreased with increasing glycerol concentration, confirming the very high crosslinking capacity of glycerol.",

keywords = "Bioadhesion, Carbopol, Crosslinking, Dissolution, Glycerol, Hydrogel, Metoclopramide, Swelling",

author = "{Garc{\'i}a Gonz{\'a}lez}, N. and Kellaway, {I. W.} and {Blanco Fuente}, H. and {Anguiano Igea}, S. and {Delgado Charro}, B. and {Otero Espinar}, {F. J.} and {Blanco M{\'e}ndez}, J.",

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doi = "10.1016/0378-5173(94)90185-6",

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T1 - Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels

AU - García González, N.

AU - Kellaway, I. W.

AU - Blanco Fuente, H.

AU - Anguiano Igea, S.

AU - Delgado Charro, B.

AU - Otero Espinar, F. J.

AU - Blanco Méndez, J.

PY - 1994/4/11

Y1 - 1994/4/11

N2 - The formulation of glycerol-crosslinked Carbopol 907 and Carbopol 941 metoclopramide hydrogels for buccal administration were investigated. Infrared spectroscopy showed that crosslinking was the result of ester formation between Carbopol carboxyl groups and glycerol hydroxyl groups. The effects of Carbopol molecular weight and glycerol concentration on swelling and drug release characteristics were evaluated. In all glycerol-containing formulations drug dissolution efficiencies were low, and both dissolution efficiency and swelling rate decreased with increasing glycerol concentration, confirming the very high crosslinking capacity of glycerol.

AB - The formulation of glycerol-crosslinked Carbopol 907 and Carbopol 941 metoclopramide hydrogels for buccal administration were investigated. Infrared spectroscopy showed that crosslinking was the result of ester formation between Carbopol carboxyl groups and glycerol hydroxyl groups. The effects of Carbopol molecular weight and glycerol concentration on swelling and drug release characteristics were evaluated. In all glycerol-containing formulations drug dissolution efficiencies were low, and both dissolution efficiency and swelling rate decreased with increasing glycerol concentration, confirming the very high crosslinking capacity of glycerol.

KW - Bioadhesion

KW - Carbopol

KW - Crosslinking

KW - Dissolution

KW - Glycerol

KW - Hydrogel

KW - Metoclopramide

KW - Swelling

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JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 2

ER -

Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels

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Keywords

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