Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels

N. García González, I. W. Kellaway, H. Blanco Fuente, S. Anguiano Igea, B. Delgado Charro, F. J. Otero Espinar, J. Blanco Méndez

Research output: Contribution to journalArticle

Abstract

The formulation of glycerol-crosslinked Carbopol 907 and Carbopol 941 metoclopramide hydrogels for buccal administration were investigated. Infrared spectroscopy showed that crosslinking was the result of ester formation between Carbopol carboxyl groups and glycerol hydroxyl groups. The effects of Carbopol molecular weight and glycerol concentration on swelling and drug release characteristics were evaluated. In all glycerol-containing formulations drug dissolution efficiencies were low, and both dissolution efficiency and swelling rate decreased with increasing glycerol concentration, confirming the very high crosslinking capacity of glycerol.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume104
Issue number2
DOIs
Publication statusPublished - 11 Apr 1994

Keywords

  • Bioadhesion
  • Carbopol
  • Crosslinking
  • Dissolution
  • Glycerol
  • Hydrogel
  • Metoclopramide
  • Swelling

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