Influence of Chemical Enhancers and Iontophoresis on the In Vitro Transdermal Permeation of Propranolol: Evaluation by Dermatopharmacokinetics

M. Aracely Calatayud Pascual, Maria Sebastian Morello, Cristina Balaguer Fernandez, Maria Delgado-Charro, Alicia Lopez-Castellano, Virginia Merino

Research output: Contribution to journalArticle

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Abstract

The aims of this study were to assess in vitro the possibility of administering propranolol transdermally and to evaluate the usefulness of the dermatopharmacokinetic (DPK) method in assessing the transport of drugs through stratum corneum, using propranolol as a model compound. Four chemical enhancers (decenoic and oleic acid, laurocapram, and R-(+)-limonene) and iontophoresis at two current densities, 0.25 and 0.5 mA/cm2 were tested. R-(+)-limonene, and iontophoresis at 0.5 mA/cm2 were proven to be the most efficient in increasing propranolol transdermal flux, both doubled the original propranolol transdermal flux. Iontophoresis was demonstrated to be superior than the chemical enhancer because it allowed faster delivery of the drug. The DPK method was sufficiently sensitive to detect subtle vehicle-induced effects on the skin permeation of propranolol. The shorter duration of these experiments and their ability to provide mechanistic information about partition between vehicle and skin and diffusivity through skin place them as practical and potentially insightful approach to quantify and, ultimately, optimize topical bioavailability.The aims of this study were to assess in vitro the possibility of administering propranolol transdermally and to evaluate the usefulness of the dermatopharmacokinetic (DPK) method in assessing the transport of drugs through stratum corneum, using propranolol as a model compound. Four chemical enhancers (decenoic and oleic acid, laurocapram, and R-(+)-limonene) and iontophoresis at two current densities, 0.25 and 0.5 mA/cm2 were tested. R-(+)-limonene, and iontophoresis at 0.5 mA/cm2 were proven to be the most efficient in increasing propranolol transdermal flux, both doubled the original propranolol transdermal flux. Iontophoresis was demonstrated to be superior than the chemical enhancer because it allowed faster delivery of the drug. The DPK method was sufficiently sensitive to detect subtle vehicle-induced effects on the skin permeation of propranolol. The shorter duration of these experiments and their ability to provide mechanistic information about partition between vehicle and skin and diffusivity through skin place them as practical and potentially insightful approach to quantify and, ultimately, optimize topical bioavailability.
Original languageEnglish
Article number265
Number of pages15
JournalPharmaceutics
Volume10
Issue number4
DOIs
Publication statusPublished - 7 Dec 2018

Keywords

  • iontophoresis; transdermal administration; dermatopharmacokinetics; propranolol; chemical enhancersiontophoresis; transdermal administration; dermatopharmacokinetics; propranolol; chemical enhancers

Cite this

Influence of Chemical Enhancers and Iontophoresis on the In Vitro Transdermal Permeation of Propranolol: Evaluation by Dermatopharmacokinetics. / Calatayud Pascual, M. Aracely; Sebastian Morello, Maria; Balaguer Fernandez, Cristina ; Delgado-Charro, Maria; Lopez-Castellano, Alicia; Merino, Virginia.

In: Pharmaceutics, Vol. 10, No. 4, 265, 07.12.2018.

Research output: Contribution to journalArticle

Calatayud Pascual, M. Aracely ; Sebastian Morello, Maria ; Balaguer Fernandez, Cristina ; Delgado-Charro, Maria ; Lopez-Castellano, Alicia ; Merino, Virginia. / Influence of Chemical Enhancers and Iontophoresis on the In Vitro Transdermal Permeation of Propranolol: Evaluation by Dermatopharmacokinetics. In: Pharmaceutics. 2018 ; Vol. 10, No. 4.
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