TY - JOUR
T1 - Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels
AU - García-González, N.
AU - Kellaway, I. W.
AU - Blanco-Fuente, H.
AU - Anguiano-Igea, S.
AU - Delgado-Charro, B.
AU - Otero-Espinar, F. J.
AU - Blanco-Méndez, J.
PY - 1993/11/8
Y1 - 1993/11/8
N2 - We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (β-cyclodextrin) concentration on swelling and drug (metoclopramide) release characteristics of PAA hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased β-cyclodextrin concentrations led to reduced swelling and reduced drug release efficiency.
AB - We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (β-cyclodextrin) concentration on swelling and drug (metoclopramide) release characteristics of PAA hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased β-cyclodextrin concentrations led to reduced swelling and reduced drug release efficiency.
KW - Bioadhesive hydrogel
KW - Carbopol
KW - Dissolution
KW - Metoclopramide
KW - Swelling
KW - β-Cyclodextrin
UR - http://www.scopus.com/inward/record.url?scp=0027429954&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/0378-5173(93)90071-M
U2 - 10.1016/0378-5173(93)90071-M
DO - 10.1016/0378-5173(93)90071-M
M3 - Article
AN - SCOPUS:0027429954
SN - 0378-5173
VL - 100
SP - 25
EP - 31
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-3
ER -