Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels

N. García-González; I. W. Kellaway; H. Blanco-Fuente; S. Anguiano-Igea; B. Delgado-Charro; F. J. Otero-Espinar; J. Blanco-Méndez

doi:10.1016/0378-5173(93)90071-M

Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels

N. García-González, I. W. Kellaway, H. Blanco-Fuente, S. Anguiano-Igea, B. Delgado-Charro, F. J. Otero-Espinar, J. Blanco-Méndez

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (β-cyclodextrin) concentration on swelling and drug (metoclopramide) release characteristics of PAA hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased β-cyclodextrin concentrations led to reduced swelling and reduced drug release efficiency.

Original language	English
Pages (from-to)	25-31
Number of pages	7
Journal	International Journal of Pharmaceutics
Volume	100
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(93)90071-M
Publication status	Published - 8 Nov 1993

Keywords

Bioadhesive hydrogel
Carbopol
Dissolution
Metoclopramide
Swelling
β-Cyclodextrin

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10.1016/0378-5173(93)90071-M

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García-González, N., Kellaway, I. W., Blanco-Fuente, H., Anguiano-Igea, S., Delgado-Charro, B., Otero-Espinar, F. J., & Blanco-Méndez, J. (1993). Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels. International Journal of Pharmaceutics, 100(1-3), 25-31. https://doi.org/10.1016/0378-5173(93)90071-M

Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels. / García-González, N.; Kellaway, I. W.; Blanco-Fuente, H. et al.
In: International Journal of Pharmaceutics, Vol. 100, No. 1-3, 08.11.1993, p. 25-31.

Research output: Contribution to journal › Article › peer-review

García-González, N, Kellaway, IW, Blanco-Fuente, H, Anguiano-Igea, S, Delgado-Charro, B, Otero-Espinar, FJ & Blanco-Méndez, J 1993, 'Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels', International Journal of Pharmaceutics, vol. 100, no. 1-3, pp. 25-31. https://doi.org/10.1016/0378-5173(93)90071-M

García-González N, Kellaway IW, Blanco-Fuente H, Anguiano-Igea S, Delgado-Charro B, Otero-Espinar FJ et al. Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels. International Journal of Pharmaceutics. 1993 Nov 8;100(1-3):25-31. doi: 10.1016/0378-5173(93)90071-M

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AU - Anguiano-Igea, S.

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Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels

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Keywords

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