Influence of β-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels

N. García-González, I. W. Kellaway, H. Blanco-Fuente, S. Anguiano-Igea, B. Delgado-Charro, F. J. Otero-Espinar, J. Blanco-Méndez

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Abstract

We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (β-cyclodextrin) concentration on swelling and drug (metoclopramide) release characteristics of PAA hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased β-cyclodextrin concentrations led to reduced swelling and reduced drug release efficiency.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume100
Issue number1-3
DOIs
Publication statusPublished - 8 Nov 1993

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Keywords

  • Bioadhesive hydrogel
  • Carbopol
  • Dissolution
  • Metoclopramide
  • Swelling
  • β-Cyclodextrin

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