Abstract
NMR spectroscopy is a powerful technique for separating and measuring each distinct pKa value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments were made for each individual amine substituent on 2-deoxystreptamine, tobramycin, kanamycin B, amikacin, sisomicin, and netilmicin using variations in the NMR spectroscopic chemical shift (δ) with 1H, 13C, and 15N HMBC; the individual pKa values of netilmicin are reported for the first time.
Original language | English |
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Pages (from-to) | 21094–21103 |
Journal | ACS OMEGA |
Volume | 5 |
Issue number | 33 |
Early online date | 11 Aug 2020 |
DOIs | |
Publication status | Published - 25 Aug 2020 |
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering