Individual and combined effects of acute delta-9-tetrahydrocannabinol and cannabidiol on psychotomimetic symptoms and memory function

Celia J A Morgan, Tom P Freeman, Chandni Hindocha, Grainne Schafer, Chelsea Gardner, H Valerie Curran

Research output: Contribution to journalArticle

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Abstract

The main active ingredient in cannabis, delta-9-tetrahydrocannabinol (THC), can acutely induce psychotic symptoms and impair episodic and working memory. Another major constituent, cannabidiol (CBD), may attenuate these effects. This study aimed to determine the effects of THC and CBD, both alone and in combination on psychotic symptoms and memory function. A randomised, double-blind crossover design compared the effects of (i) placebo, (ii) THC 8 mg, (iii) CBD 16 mg and (iv) THC 8 mg + CBD 16 mg administered by inhalation through a vaporiser. Using an experimental medicine approach to predict treatment sensitivity, we selected 48 cannabis users from the community on the basis of (1) schizotypal personality questionnaire scores (low, high) and (2) frequency of cannabis use (light, heavy). The Brief Psychiatric Rating Scale (BPRS), Psychotomimetic States Inventory (PSI), immediate and delayed prose recall (episodic memory), 1- and 2-back (working memory) were assessed on each day. Results indicated that THC increased overall scores on the PSI, negative symptoms on BPRS, and robustly impaired episodic and working memory. Co-administration of CBD did not attenuate these effects. CBD alone reduced PSI scores in light users only. At a ratio of 2:1, CBD does not attenuate the acute psychotic and memory impairing effects of vaporised THC. Frequent cannabis users may show a blunted anti- psychotic response to CBD, which is of concern due to the high rates of cannabis use disorders in patients with schizophrenia.

Original languageEnglish
Article number181
Number of pages10
JournalTranslational Psychiatry
Volume8
Issue number1
DOIs
Publication statusPublished - 5 Sep 2018

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Cannabidiol
Dronabinol
Cannabis
Episodic Memory
Short-Term Memory
Brief Psychiatric Rating Scale
Equipment and Supplies
Light
Placebo Effect
Nebulizers and Vaporizers
Cross-Over Studies
Inhalation
Personality
Biomedical Research
Schizophrenia

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Individual and combined effects of acute delta-9-tetrahydrocannabinol and cannabidiol on psychotomimetic symptoms and memory function. / Morgan, Celia J A; Freeman, Tom P; Hindocha, Chandni; Schafer, Grainne; Gardner, Chelsea; Curran, H Valerie.

In: Translational Psychiatry, Vol. 8, No. 1, 181, 05.09.2018.

Research output: Contribution to journalArticle

Morgan, Celia J A ; Freeman, Tom P ; Hindocha, Chandni ; Schafer, Grainne ; Gardner, Chelsea ; Curran, H Valerie. / Individual and combined effects of acute delta-9-tetrahydrocannabinol and cannabidiol on psychotomimetic symptoms and memory function. In: Translational Psychiatry. 2018 ; Vol. 8, No. 1.
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