The indium catalysed additions of electron-rich alkenes and heteroaromatics to an activated α-imino ester is described. The moisture-sensitive substrate is prepared in situ facilitating a convenient synthesis of unnatural α-amino acid derivatives in one-pot from commercially available reagents.
Krakowski, M., Frost, C. G., Hartley, J. P., & Chauhan, K. K. (2006). Indium triflate catalysed Ene and Friedel Crafts additions to α-imino esters: A one-pot synthesis of α-amino acid derivatives. Letters in Organic Chemistry, 3(3), 228-230. https://doi.org/10.2174/157017806775789921